Evidence map›Paper›PMID 31614475›Full record

ArticleInternational journal of molecular sciences2019

Functional Consequences of the

Simona Casini, Maxime Albesa, Zizun Wang, Vincent Portero, Daniela Ross-Kaschitza, Jean-Sébastien Rougier, Gerard A Marchal, Wendy K Chung, Connie R Bezzina, Hugues Abriel and 1 more

Abstract readCase ReportsComparative Study
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. High-Throughput Reclassification of SCN5A Variants.American journal of human genetics · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Simona CasiniDepartment of Clinical and Experimental Cardiology, Heart Centre, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 Amsterdam, The Netherlands. s.casini@amsterdamumc.nl.ORCID 0000-0002-2672-2779
Maxime AlbesaIon Channels and Channelopathies Laboratory, Institute for Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland. maxime.albesa@zeiss.com.
Zizun WangIon Channels and Channelopathies Laboratory, Institute for Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland. zizun.wang@ibmm.unibe.ch.
Vincent PorteroDepartment of Clinical and Experimental Cardiology, Heart Centre, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 Amsterdam, The Netherlands. v.m.portero@amsterdamumc.nl.ORCID 0000-0002-7221-859X
Daniela Ross-KaschitzaIon Channels and Channelopathies Laboratory, Institute for Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland. daniela.ross@ibmm.unibe.ch.
Jean-Sébastien RougierIon Channels and Channelopathies Laboratory, Institute for Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland. jean-sebastien.rougier@ibmm.unibe.ch.ORCID 0000-0002-8710-0260
Gerard A MarchalDepartment of Clinical and Experimental Cardiology, Heart Centre, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 Amsterdam, The Netherlands. g.a.marchal@amsterdamumc.nl.
Wendy K ChungDepartments of Pediatrics & Medicine, Columbia University Medical Center, 1150 St Nicholas Avenue, New York, NY 10032, USA. wkc15@cumc.columbia.edu.ORCID 0000-0003-3438-5685
Connie R BezzinaDepartment of Clinical and Experimental Cardiology, Heart Centre, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 Amsterdam, The Netherlands. c.r.bezzina@amsterdamumc.nl.
Hugues AbrielIon Channels and Channelopathies Laboratory, Institute for Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland. Hugues.Abriel@ibmm.unibe.ch.ORCID 0000-0003-0465-5138
Carol Ann RemmeDepartment of Clinical and Experimental Cardiology, Heart Centre, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 Amsterdam, The Netherlands. c.a.remme@amsterdamumc.nl.ORCID 0000-0003-0095-0084

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Division for Earth and Life Sciences with financial aid from the Netherlands Organization for Scientific Research (NWO) ALW; 836.09.003 to C.A.RInnovational Research Incentives Scheme Vidi grant from the Netherlands Organisation for Health Research and Development ZonMw; 91714371 to C.A.R.InterUniversity Cardiology Institute of the Netherlands 061.02 to C.A.R. and C.R.B.JPB Foundation wkc15 to W.K.C.NCATS NIH HHS UL1 TR001863Netherlands CardioVascular Research Initiative CVON (Dutch Heart Foundation, Dutch Federation of University Medical Centres, ZonMw, the Royal Netherlands Academy of Sciences) projects PREDICT CVON2012-10 to C.R.B.Swiss National Science Foundation #310030B-135693 to H.A.
6 · The paper itself

Abstract

Dysfunction of the cardiac sodium channel Nav1.5 (encoded by the

Indexed as

Amino Acid SubstitutionAmino Acid MotifsAnimalsFemaleGene Knock-In TechniquesHEK293 CellsHumansLong QT SyndromeMiceMice, TransgenicNAV1.5 Voltage-Gated Sodium ChannelNedd4 Ubiquitin Protein LigasesProtein BindingUbiquitinationYoung AdultNAV1.5 Voltage-Gated Sodium ChannelNedd4L protein, humanNedd4 Ubiquitin Protein LigasesSCN5A protein, humanScn5a protein, mouseaction potentiallong QT syndromemouse modelNedd4-2patch-clampSCN5Asodium currentubiquitylation

Identifiers

PMID31614475
PMCPMC6829230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.