Evidence map›Paper›PMID 31614437›Full record

ReviewInternational journal of molecular sciences2019

Autophagy, Metabolism, and Alcohol-Related Liver Disease: Novel Modulators and Functions.

Shengmin Yan, Bilon Khambu, Honghai Hong, Gang Liu, Nazmul Huda, Xiao-Ming Yin

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Autophagy in the liver.Autophagy reports · 2026
    Review
  2. MedComm · 2023
    Article
  3. Review
  4. Article
  5. Review
  6. Xenobiotic-Induced Aggravation of Metabolic-Associated Fatty Liver Disease.International journal of molecular sciences · 2022
    Review
  7. Autophagy in liver diseases.World journal of hepatology · 2021
    Review
  8. miR-151 Affects Low-Temperature Tolerance ofFrontiers in cell and developmental biology · 2021
    Article
  9. [Autophagy in the liver failure].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2020
    Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shengmin YanDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. yan29@iupui.edu.ORCID 0000-0003-4012-9557
Bilon KhambuDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. bikhambu@iupui.edu.ORCID 0000-0002-9432-2064
Honghai HongDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. honghong@iu.edu.
Gang LiuDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. gangliu@iu.edu.
Nazmul HudaDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. nhuda@iu.edu.ORCID 0000-0002-7788-8621
Xiao-Ming YinDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. xmyin@iu.edu.
Indiana University School of Medicine

Funding

The dynamics and mechanisms of autophagy in ethanol - induced liver pathogenesisR01AA021751 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI TSUKAMOTO, HIDEKAZU, YIN, XIAO-MING · 2013 to 2017
$2.1M
The Role of HMGB1 in autophagy deficiency-induced liver pathologyR01DK116605 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI YIN, XIAO-MING · 2018 to 2021
$1.7M
NIDDK NIH HHS R01 DK116605NIH HHS R01AA021751NIH HHS R01DK116605
6 · The paper itself

Abstract

Alcohol-related liver disease (ALD) is caused by over-consumption of alcohol. ALD can develop a spectrum of pathological changes in the liver, including steatosis, inflammation, cirrhosis, and complications. Autophagy is critical to maintain liver homeostasis, but dysfunction of autophagy has been observed in ALD. Generally, autophagy is considered to protect the liver from alcohol-induced injury and steatosis. In this review, we will summarize novel modulators of autophagy in hepatic metabolism and ALD, including autophagy-mediating non-coding RNAs (ncRNAs), and crosstalk of autophagy machinery and nuclear factors. We will also discuss novel functions of autophagy in hepatocytes and non-parenchymal hepatic cells during the pathogenesis of ALD and other liver diseases.

Indexed as

AnimalsAutophagyGene Expression RegulationHumansLiverLiver Diseases, AlcoholicReceptors, Cytoplasmic and NuclearRNA, UntranslatedReceptors, Cytoplasmic and NuclearRNA, Untranslatedalcohol-related liver diseaseautophagyncRNAnon-parenchymal cellnuclear receptor

Identifiers

PMID31614437
PMCPMC6834312
OpenAlexW2979351013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.