Evidence map›Paper›PMID 31614255›Full record

ArticleDevelopmental cognitive neuroscience2019

Identifying reproducible individual differences in childhood functional brain networks: An ABCD study.

Scott Marek, Brenden Tervo-Clemmens, Ashley N Nielsen, Muriah D Wheelock, Ryland L Miller, Timothy O Laumann, Eric Earl, William W Foran, Michaela Cordova, Olivia Doyle and 18 more

Abstract read
In one paragraph

Article in Developmental cognitive neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  14. Considerations for conducting developmental neuroimaging research on mental health topics.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
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  20. Action-mode subnetworks for decision-making, action control, and feedback.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Scott MarekDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, 63110, USA. Electronic address: smarek@wustl.edu.
Brenden Tervo-ClemmensDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Ashley N NielsenDepartment of Medical Social Sciences, Northwestern University, Chicago, IL 60611, USA.
Muriah D WheelockDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, 63110, USA.
Ryland L MillerDepartment of Neurology, Washington University in St. Louis, St. Louis, MO, 63110, USA.
Timothy O LaumannDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, 63110, USA.
Eric EarlDepartments of Psychiatry & Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97213, USA.
William W ForanDepartment of Psychiatry, University of Pittsburgh, Pittsburgh PA, 15213, USA.
Michaela CordovaDepartments of Psychiatry & Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97213, USA.
Olivia DoyleDepartments of Psychiatry & Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97213, USA.
Anders PerroneDepartments of Psychiatry & Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97213, USA.
Oscar Miranda-DominguezDepartments of Psychiatry & Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97213, USA.
Eric FeczkoDepartments of Psychiatry & Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97213, USA; Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, OR, 97213, USA.
Darrick SturgeonDepartments of Psychiatry & Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97213, USA.
Alice GrahamDepartments of Psychiatry & Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97213, USA.
Robert HermosilloDepartments of Psychiatry & Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97213, USA.
Kathy SniderDepartments of Psychiatry & Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97213, USA.
Anthony GalassiDepartments of Psychiatry & Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97213, USA.
Bonnie J NagelDepartments of Psychiatry & Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97213, USA.
Sarah W Feldstein EwingDepartments of Psychiatry & Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97213, USA.
Adam T EggebrechtMallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, 63110, USA.
Hugh GaravanDepartment of Psychiatry, University of Vermont, Burlington VT 05401, USA.
Anders M DaleDepartment of Radiology, University of California San Diego, San Diego, CA, USA.
Deanna J GreeneDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, 63110, USA; Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, 63110, USA.
Deanna M BarchDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, 63110, USA; Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, 63110, USA; Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA.
Damien A FairDepartments of Psychiatry & Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97213, USA.
Beatriz LunaDepartment of Psychiatry, University of Pittsburgh, Pittsburgh PA, 15213, USA.
Nico U F DosenbachDepartment of Neurology, Washington University in St. Louis, St. Louis, MO, 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, 63110, USA; Department of Pediatrics, Washington University in St. Louis, St. Louis, MO, 63110, USA; Department of Radiology, Washington University in St. Louis, St. Louis, MO, 63110, USA.

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7M
ABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5M
Adolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5M
ABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7M
ABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9M
TRAINING PROGRAM IN HEALTH INFORMATICST15LM007088 · NLM · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAM R HERSH, Vishnu Mohan · 1992 to 2026
$23.4M
ABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3M
ABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7M
Supplement to Prevention Research Center: Parenting Among Women Who Are Opioid Users, Project 2P50DA048756 · NIDA · UNIVERSITY OF OREGON · PI LEVE, LESLIE DIANE · 2019 to 2023
$18.0M
Refinement of Brain Mechanisms Underlying the Developmental Stabilization from Adolescent to Adult Neurocognitive ProcessingR01MH067924 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BEATRIZ LUNA · 2004 to 2026
$14.0M
NCATS NIH HHS UL1 TR002345NCATS NIH HHS UL1 TR002369NIBIB NIH HHS K99 EB029343NIDA NIH HHS P50 DA048756NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041174NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIMH NIH HHS K01 MH103594NIMH NIH HHS K01 MH104592NIMH NIH HHS R01 MH067924NIMH NIH HHS R01 MH096773NIMH NIH HHS R01 MH105538NIMH NIH HHS R01 MH111359NIMH NIH HHS R01 MH115357NIMH NIH HHS R03 MH113090NIMH NIH HHS R25 MH112473NIMH NIH HHS T32 MH100019NINDS NIH HHS K23 NS088590NLM NIH HHS T15 LM007088
6 · The paper itself

Abstract

The 21-site Adolescent Brain Cognitive Development (ABCD) study provides an unparalleled opportunity to characterize functional brain development via resting-state functional connectivity (RSFC) and to quantify relationships between RSFC and behavior. This multi-site data set includes potentially confounding sources of variance, such as differences between data collection sites and/or scanner manufacturers, in addition to those inherent to RSFC (e.g., head motion). The ABCD project provides a framework for characterizing and reproducing RSFC and RSFC-behavior associations, while quantifying the extent to which sources of variability bias RSFC estimates. We quantified RSFC and functional network architecture in 2,188 9-10-year old children from the ABCD study, segregated into demographically-matched discovery (N = 1,166) and replication datasets (N = 1,022). We found RSFC and network architecture to be highly reproducible across children. We did not observe strong effects of site; however, scanner manufacturer effects were large, reproducible, and followed a "short-to-long" association with distance between regions. Accounting for potential confounding variables, we replicated that RSFC between several higher-order networks was related to general cognition. In sum, we provide a framework for how to characterize RSFC-behavior relationships in a rigorous and reproducible manner using the ABCD dataset and other large multi-site projects.

Indexed as

BrainBrain MappingChildFemaleHumansIndividualityMagnetic Resonance ImagingMaleABCDCognitive abilityDevelopmentFunctional connectivityReproducibilityResting state fMRI

Identifiers

PMID31614255
PMCPMC6927479

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.