Evidence map›Paper›PMID 31614211›Full record

ArticleRespiratory physiology & neurobiology2020

Time and dose-dependent impairment of neonatal respiratory motor activity after systemic inflammation.

Nina R Morrison, Stephen M Johnson, Austin D Hocker, Rebecca S Kimyon, Jyoti J Watters, Adrianne G Huxtable

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory physiology & neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
  5. Article
  6. The Impact of Inflammation on Thermal Hyperpnea: Relevance for Heat Stress and Febrile Seizures.American journal of respiratory cell and molecular biology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nina R MorrisonDepartment of Human Physiology, University of Oregon, Eugene, OR, 97403, United States.
Stephen M JohnsonDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, 53706, United States.
Austin D HockerDepartment of Human Physiology, University of Oregon, Eugene, OR, 97403, United States.
Rebecca S KimyonDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, 53706, United States.
Jyoti J WattersDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, 53706, United States.
Adrianne G HuxtableDepartment of Human Physiology, University of Oregon, Eugene, OR, 97403, United States. Electronic address: huxtable@uoregon.edu.
University of Oregon · USUniversity of Wisconsin–Madison · US

Funding

Neonatal inflammation impairs control of breathingR01HL141249 · NHLBI · UNIVERSITY OF OREGON · PI HUXTABLE, ADRIANNE GENEST · 2018 to 2022
$2.0M
Regulation of microglial plasticity by TLR4 and microRNAsR01NS085226 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI WATTERS, JYOTI J · 2015 to 2019
$1.7M
NHLBI NIH HHS R01 HL141249NINDS NIH HHS R01 NS085226
6 · The paper itself

Abstract

Neonatal respiratory impairment during infection is common, yet its effects on respiratory neural circuitry are not fully understood. We hypothesized that the timing and severity of systemic inflammation is positively correlated with impairment in neonatal respiratory activity. To test this, we evaluated time- and dose-dependent impairment of in vitro fictive respiratory activity. Systemic inflammation (induced by lipopolysaccharide, LPS, 5 mg/kg, i.p.) impaired burst amplitude during the early (1 h) inflammatory response. The greatest impairment in respiratory activity (decreased amplitude, frequency, and increased rhythm disturbances) occurred during the peak (3 h) inflammatory response in brainstem-spinal cord preparations. Surprisingly, isolated medullary respiratory circuitry within rhythmic slices showed decreased baseline frequency and delayed onset of rhythm only after higher systemic inflammation (LPS 10 mg/kg) early in the inflammatory response (1 h), with no impairments at the peak inflammatory response (3 h). Thus, different components of neonatal respiratory circuitry have differential temporal and dose sensitivities to systemic inflammation, creating multiple windows of vulnerability for neonates after systemic inflammation.

Indexed as

InflammationMedulla OblongataPeriodicityRespirationSpinal CordAnimalsAnimals, NewbornDisease Models, AnimalFemaleGene ExpressionLipopolysaccharidesMaleMotor ActivityRats, Sprague-DawleyLipopolysaccharidesAcute systemic inflammationBrainstem-spinal cordLipopolysaccharideNeonatal inflammationRhythmic slice

Identifiers

PMID31614211
PMCPMC6954283
OpenAlexW2980022513

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.