ArticleThe Annals of thoracic surgery2020
Incidence and Risk Factors for Isolated Esophageal Cancer Recurrence to the Brain.
Article in The Annals of thoracic surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 29 citations in OpenAlex.
- Incidence and prognosis of brain metastases in esophageal carcinoma: a systematic review and meta-analysis.Journal of thoracic disease · 2025Article
- Differences in esophageal adenocarcinoma survival and treatment modalities by III/IV stage subgroup: a SEER population-based study.Translational cancer research · 2025Article
- Heterochronic gastric adenosquamous carcinoma combined with colonic adenoma: A case report.World journal of gastrointestinal oncology · 2025Article
- Early Brain Metastasis despite Pathological Complete Response after Radical Resection for Esophageal Cancer following Chemotherapy and Pembrolizumab.Surgical case reports · 2025Article
- Leptomeningeal carcinomatosis and brain metastases in gastroesophageal carcinoma: a real-world analysis of clinical and pathologic characteristics and outcomes.Journal of neuro-oncology · 2024Article
- Esophageal Adenocarcinoma Presenting as an Isolated Brain Lesion 6 Years After Treatment.ACG case reports journal · 2024Article
- Prognostic value of Mandard score and nodal status for recurrence patterns and survival after multimodal treatment of oesophageal adenocarcinoma.The British journal of surgery · 2024Article
- Patients with Isolated Brain Metastases from Esophageal Carcinoma After Minimally Invasive Esophagectomy May Not Have a Dismal Prognosis.Journal of gastrointestinal cancer · 2023Article
- Outcomes and Molecular Features of Brain Metastasis in Gastroesophageal Adenocarcinoma.JAMA network open · 2022Article
- Post-recurrence survival analysis in patients with oligo-recurrence after curative esophagectomy.BMC cancer · 2022Article
- Current status of gastrointestinal tract cancer brain metastasis and the use of blood-based cancer biomarker biopsy.Clinical & experimental metastasis · 2022Review
- Survival Prediction Model for Patients with Esophageal Squamous Cell Carcinoma Based on the Parameter-Optimized Deep Belief Network Using the Improved Archimedes Optimization Algorithm.Computational and mathematical methods in medicine · 2022Article
- A population-based investigation: How to identify high-risk T1-2N0 esophageal cancer patients?Frontiers in surgery · 2022Article
- Oligometastases After Curative Esophagectomy Are Not One Size Fits All.The Annals of thoracic surgery · 2021Article
- The risk and prognostic factors for brain metastases in esophageal cancer patients: an analysis of the SEER database.BMC cancer · 2021Article
- Presentation of gastroesophageal junction adenocarcinoma with synchronous metastases at the small intestine. Could treatment with curative intent be considered? A case report.International journal of surgery case reports · 2021Article
- A Rare Case of Metastatic Esophageal Adenocarcinoma Presenting as an Isolated Cerebellar Lesion 5 Years After Treatment.Hawai'i journal of health & social welfare · 2021Article
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12 authors at 4 institutions in 1 country.
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Abstract
backgroundRecurrence of esophageal cancer in the brain is rare but associated with a poor prognosis. Identification of risk factors for isolated brain metastasis of esophageal cancer (iBMEC) after surgical treatment may guide surveillance recommendations to enable early identification and intervention before widespread metastasis.
methodsPatients with iBMEC (n = 38) were identified from a prospective database of patients with esophageal cancer who underwent esophagectomy. Risk factors for iBMEC were identified using competing risk regression analysis.
resultsIn a cohort of 1760 patients, 39% recurred and iBMEC developed in 2% by the end of the study. Survival in patients with iBMEC was similar to survival in patients with distant recurrence (median overall survival, 0.95 years; 95% confidence interval, 0.6-1.5 years). More than half of patients with iBMEC were diagnosed within 1 year postoperatively. All 38 patients with iBMEC had received neoadjuvant therapy before surgery. Pathologic complete response (PCR) to neoadjuvant therapy was associated with improved survival after brain recurrence (median overall survival, 1.56 vs 0.66 years; P = .019).
conclusionsIn patients with PCR, iBMEC may represent true isolated recurrence, whereas in those with residual nodal disease, iBMEC may actually be the first observed site of widespread metastasis. Patients who receive neoadjuvant therapy, especially with PCR, may benefit from brain imaging, both preoperatively and with routine surveillance.
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