Evidence map›Paper›PMID 31614121›Full record

ReviewExperimental neurology2020

GluT4: A central player in hippocampal memory and brain insulin resistance.

Ewan C McNay, Jiah Pearson-Leary

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 3 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 3 syntheses or guidelines pooled it, 142 citations in OpenAlex.

  1. Pooled it
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  4. Trial
  5. Holdfast-Derived Lipid Extract from the Patagonian MacroalgaPharmaceuticals (Basel, Switzerland) · 2026
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ewan C McNayBehavioral Neuroscience, University at Albany, Albany, NY, USA. Electronic address: emcnay@albany.edu.
Jiah Pearson-LearyDepartment of Anesthesiology, Abramson Research Center, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Children's Hospital of Philadelphia · USUniversity at Albany, State University of New York · US

Funding

Mechanisms transducing insulin and insulin resistance in the hippocampusR01AG050598 · NIA · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI MCNAY, EWAN C · 2016 to 2020
$1.9M
Insulin in the hippocampus: memory enhancement and impact of type 2 diabetesR01DK077106 · NIDDK · YALE UNIVERSITY · PI MCNAY, EWAN C · 2007 to 2011
$1.4M
CNS HIV ANTI-RETROVIRAL THERAPY EFFECTS RESEARCH /CHARTER/ -278022005-278022005N01MH022005 · NIMH · UNIVERSITY OF CA -SAN DIEGO · PI GRANT, IGOR · 2003 to 2006
–
NIA NIH HHS R01 AG050598NIDDK NIH HHS R01 DK077106NIMH NIH HHS HHSN271201000030CNIMH NIH HHS HHSN271201000036CNIMH NIH HHS N01 MH022005
6 · The paper itself

Abstract

Insulin is now well-established as playing multiple roles within the brain, and specifically as regulating hippocampal cognitive processes and metabolism. Impairments to insulin signaling, such as those seen in type 2 diabetes and Alzheimer's disease, are associated with brain hypometabolism and cognitive impairment, but the mechanisms of insulin's central effects are not determined. Several lines of research converge to suggest that the insulin-responsive glucose transporter GluT4 plays a central role in hippocampal memory processes, and that reduced activation of this transporter may underpin the cognitive impairments seen as a consequence of insulin resistance.

Indexed as

AnimalsCognitive DysfunctionGlucose Transporter Type 4HippocampusHumansInsulin ResistanceMemoryGlucose Transporter Type 4

Identifiers

PMID31614121
PMCPMC6936336
OpenAlexW2980172305

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.