Evidence map›Paper›PMID 31614008›Full record

ArticleClinical endocrinology2019

Maternal cognitive function during pregnancy in relation to hypo- and hyperthyroxinemia.

Victor J Pop, Vlad Ormindean, Andreia Mocan, Margreet Meems, Maarten Broeren, Johan K Denollet, Wilmar M Wiersinga, Adomas Bunevicius

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. [Unveiling Hormonal Secrets]Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Victor J PopDepartment of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands.ORCID 0000-0003-2732-7137
Vlad OrmindeanIuliu Hațieganu, University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Andreia MocanCenter for Diabetes, Nutrition and Metabolic Diseases, Emergency Clinical County Hospital, Cluj-Napoca, Romania.
Margreet MeemsDepartment of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands.
Maarten BroerenMaxima Medical Hospital, Veldhoven, The Netherlands.
Johan K DenolletDepartment of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands.
Wilmar M WiersingaDepartment of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Adomas BuneviciusComputational Neuroscience Outcomes Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Tilburg University · NLAmsterdam UMC Location University of Amsterdam · NLBrigham and Women's Hospital · USClinical Emergency Hospital Bucharest · ROIuliu Hațieganu University of Medicine and Pharmacy · RORadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess a possible relationship between maternal cognitive dysfunction during pregnancy and hypothyroxinemia, adjusted for major confounders.

backgroundThyroid dysfunction in general is associated with cognitive dysfunction. Cognitive dysfunction is common during pregnancy.

designProspective follow-up study from 12 to 32 weeks of pregnancy.

participants2082 healthy pregnant women. MEASUREMENTS: Cognitive function, depression and sleeping problems were assessed by self-report questionnaires at 12, 22 and 32 weeks of gestation, higher scores reflecting more symptoms. FT4, TSH and TPO-Ab were assessed at 12 weeks of gestation. DEFINITIONS: healthy (euthyroxinemia) control group: FT4 within 10-90th percentiles, without elevated TPO-Ab titres and TSH within first trimester-specific reference range (0.23-4.0 mU/L). Hypothyroxinemia: FT4 <2.5th percentile with TSH within first trimester-specific reference range. Poor cognitive function: a score >1 SD > mean on the cognitive function scale.

resultsA total of 54 women showed hypothyroxinemia and 1476 women had euthyroxinemia. At 12 weeks, multiple logistic regression showed that poor cognitive function was independently related to hypothyroxinemia: OR: 2.9 (95% CI: 1.6-5.4), adjusted for depression (OR: 3.1; 95% CI: 2.7-4.6) and sleeping problems (OR: 2.8, 95% CI: 1.9-3.9). TPO-Ab + women with hypothyroxinemia had the highest levels of cognitive dysfunction. Other cut-offs of hypothyroxinemia (<5th or <10th percentile with normal TSH) showed similar results. GLM-ANOVA showed that throughout pregnancy women with hypothyroxinemia at 12 weeks had significantly higher cognitive dysfunction scores compared with the healthy controls: F = 12.1, P = .001.

conclusionsWomen with hypothyroxinemia during early gestation are at risk for poor cognitive function throughout gestation, adjusted for depression and sleeping problems.

Indexed as

AdultCognitionCognitive DysfunctionDepressionFemaleGestational AgeHumansHyperthyroxinemiaPregnancyProspective StudiesSleepSurveys and QuestionnairesThyroid Function TestsThyroid Glandcognitive functionhypothyroxinemiapregnancythyroid

Identifiers

PMID31614008
PMCPMC6900117
OpenAlexW2981148668

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.