ArticlePloS one2019
Molecular detection and genetic characterization of Bartonella species from rodents and their associated ectoparasites from northern Tanzania.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Impact of habitat modifications on flea (Siphonaptera) infestation dynamics of non-volant small mammals across wildlife-human interfaces in Tanzania.International journal for parasitology. Parasites and wildlife · 2026Article
- Genetic diversity of Bartonella species in small mammals in the Qinghai Menyuan section of Qilian Mountain National Park, China.Scientific reports · 2024Article
- Metagenomic Detection of Bacterial Zoonotic Pathogens among Febrile Patients, Tanzania, 2007-2009Emerging infectious diseases · 2024Article
- Prevalence and diversity of small rodent-associated Bartonella species in Shangdang Basin, China.PLoS neglected tropical diseases · 2022Article
- Emerging rodent-associated Bartonella: a threat for human health?Parasites & vectors · 2022Review
- Detection of Potential ZoonoticMicroorganisms · 2022Article
- Genetic variations and microbiome of the poultry red miteFrontiers in microbiology · 2022Article
- Molecular Detection ofMicroorganisms · 2021Article
- Occurrence of Multidrug-ResistantInternational journal of environmental research and public health · 2021Article
- Comparison of Serological and Molecular Assays forPathogens (Basel, Switzerland) · 2021Article
- Article
- Bartonella gabonensis sp. nov., a new bartonella species from savannah rodent Lophuromys sp. in Franceville, Gabon.New microbes and new infections · 2020Article
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundBartonellae are intracellular bacteria, which can cause persistent bacteraemia in humans and a variety of animals. Several rodent-associated Bartonella species are human pathogens but data on their global distribution and epidemiology are limited. The aims of the study were to: 1) determine the prevalence of Bartonella infection in rodents and fleas; 2) identify risk factors for Bartonella infection in rodents; and 3) characterize the Bartonella genotypes present in these rodent and flea populations. METHODS AND
resultsSpleen samples collected from 381 rodents representing six different species were tested for the presence of Bartonella DNA, which was detected in 57 individuals (15.0%; 95% CI 11.3-18.5), of three rodent species (Rattus rattus n = 54, Mastomys natalensis n = 2 and Paraxerus flavovottis n = 1) using a qPCR targeting the ssrA gene. Considering R. rattus individuals only, risk factor analysis indicated that Bartonella infection was more likely in reproductively mature as compared to immature individuals (OR = 3.42, p <0.001). Bartonella DNA was also detected in 53 of 193 Xenopsylla cheopis fleas (27.5%: 95% CI 21.3-34.3) collected from R.rattus individuals. Analysis of ssrA and gltA sequences from rodent spleens and ssrA sequences from fleas identified multiple genotypes closely related (≥ 97% similar) to several known or suspected zoonotic Bartonella species, including B. tribocorum, B. rochalimae, B. elizabethae and B. quintana.
conclusionsThe ssrA and gltA sequences obtained from rodent spleens and ssrA sequences obtained from fleas reveal the presence of a diverse set of Bartonella genotypes and increase our understanding of the bartonellae present in Tanzanian. Further studies are needed to fully characterise the prevalence, genotypes and diversity of Bartonella in different host populations and their potential impacts on human health.
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