ArticlePloS one2019
The accumulation of deficits approach to describe frailty.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- The impact of interventions on management of frailty in hospitalized frail older adults: a systematic review and meta-analysis.BMC geriatrics · 2020Pooled it
- Validation of a Deficit-Accumulation Frailty Index in the ASPirin in Reducing Events in the Elderly Study and Its Predictive Capacity for Disability-Free Survival.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Trial
- The Implementation of Frailty Assessment Tools in the Acute Care Setting: A Scoping Review.Journal of the American Geriatrics Society · 2025Article
- Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling.Nature genetics · 2025Article
- Frailty in Kingdom of Saudi Arabia-Prevalence and Management, Where Are We?Healthcare (Basel, Switzerland) · 2023Article
- Development of a frailty index from the Dutch public health monitor 2016 and investigation of its psychometric properties: a cross-sectional study.Archives of public health = Archives belges de sante publique · 2023Article
- Article
- Associations among frailty and quality of life in older patients with cancer treated with chemotherapy.Journal of geriatric oncology · 2022Article
- Heath status, frailty, and multimorbidity in patients with emergency general surgery conditions.Surgery · 2022Article
- Metastatic Colorectal Cancer Outcomes by Age Among ARCAD First- and Second-Line Clinical Trials.JNCI cancer spectrum · 2022Article
- Physiological aging around the World.PloS one · 2022Article
- Social vulnerability and aging of elderly people in the United States.SSM - population health · 2021Article
- Longevity leap: mind the healthspan gap.NPJ Regenerative medicine · 2021Review
- The Importance of Age in the Prediction of Mortality by a Frailty Index: A Machine Learning Approach in the Irish Longitudinal Study on Ageing.Geriatrics (Basel, Switzerland) · 2021Article
- Sleep duration and incident frailty: The Rural Frailty Study.BMC geriatrics · 2021Article
- Aging in the USA: similarities and disparities across time and space.Scientific reports · 2020Article
- Serum branched-chain amino acids are associated with leukocyte telomere length and frailty based on residents from Guangxi longevity county.Scientific reports · 2020Article
- Using a genetic algorithm to derive a highly predictive and context-specific frailty index.Aging · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The advancing age of the participants of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study was the incentive to investigate frailty as a major parameter of ageing. The aim of this study was to develop a multidimensional tool to measure frailty in an ageing, free-living study population. The "accumulation of deficits approach" was used to develop a frailty index (FI) to characterize a sub-sample (N = 815) of the EPIC-Potsdam (EPIC-P) study population regarding the aging phenomenon. The EPIC-P frailty index (EPIC-P-FI) included 32 variables from the following domains: health, physical ability, psychosocial and physiological aspects. P-values were calculated for the linear trend between sociodemographic and life style variables and the EPIC-P-FI was calculated using regression analysis adjusted for age. The relationship between the EPIC-P-FI and age was investigated using fractional polynomials. Some characteristics such as age, education, time spent watching TV, cycling and a biomarker of inflammation (C-reactive protein) were associated with frailty in men and women. Interestingly, living alone, having no partner and smoking status were only associated with frailty in men, and alcohol use and physical fitness (VO2max) only in women. The generated, multidimensional FI, adapted to the EPIC-P study, showed that this cohort is a valuable source for further exploration of factors that promote healthy ageing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.