ArticlePLoS biology2019
Refining animal research: The Animal Study Registry.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Efficacy of combined targeted radionuclide therapy and immune checkpoint Inhibition in animal tumour models: a systematic review and meta-analysis of the literature.European journal of nuclear medicine and molecular imaging · 2025Pooled it
- Therapeutic effects and potential mechanisms of astragaloside IV on pulmonary fibrosis: a systematic review and meta-analysis of preclinical studies.Frontiers in pharmacology · 2025Pooled it
- Good Practice Guideline for Preclinical Alcohol Research: The STRINGENCY Framework.Current topics in behavioral neurosciences · 2025Guideline
- Photobiomodulation therapy on skeletal muscles exposed to diabetes mellitus: a systematic review of animal studies.Lasers in medical science · 2023Pooled it
- Uncovering the "riddle of femininity" in osteoarthritis: a systematic review and meta-analysis of menopausal animal models and mathematical modeling of estrogen treatment.Osteoarthritis and cartilage · 2023Pooled it
- Risk of bias and reporting practices in studies comparing VOJournal of sport and health science · 2022Pooled it
- Preregistration of Preclinical Animal Studies as a Tool for Refinement: A Feasibility Study Comparing the German Animal Study Registry and Preclinicaltrials.eu.Animals : an open access journal from MDPI · 2026Article
- A survey of researchers' attitudes to preregistration in animal research reveals multiple perceived barriers to adoption.PLoS biology · 2026Article
- Improving the transparency of animal experiments: valuable lessons learned from a systematic analysis of registration protocols.BMC veterinary research · 2026Article
- Testing the reproducibility of ecological studies on insect behavior in a multi-laboratory setting identifies opportunities for improving experimental rigor.PLoS biology · 2025Article
- Menopause-induced 17β-estradiol and progesterone loss increases senescence markers, matrix disassembly and degeneration in mouse cartilage.Nature aging · 2025Article
- A mapping review of worldwide current and previous cohort research programmes in cats and dogs.PloS one · 2025Review
- 3R centres contributions to change animal experimentation : A field report from Charité 3EMBO reports · 2024Article
- Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments.EFSA journal. European Food Safety Authority · 2024Article
- Open Science 2.0: Towards a truly collaborative research ecosystem.PLoS biology · 2023Article
- Rehoming and Other Refinements and Replacement in Procedures Using Golden Hamsters in SARS-CoV-2 Vaccine Research.Animals : an open access journal from MDPI · 2023Article
- Designing, conducting, and reporting reproducible animal experiments.The Journal of endocrinology · 2023Review
- The Importance of Animal Models in Biomedical Research: Current Insights and Applications.Animals : an open access journal from MDPI · 2023Review
- Poor Reporting Quality in Basic Nutrition Research: A Case Study Based on a Scoping Review of Recent Folate Research in Mouse Models (2009-2021).Advances in nutrition (Bethesda, Md.) · 2022Article
- Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart.Cardiovascular research · 2022Article
Corrections and comments
- Commented on by
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Animal Study Registry (ASR; www.animalstudyregistry.org) was launched in January 2019 for preregistration of animal studies in order to increase transparency and reproducibility of bioscience research and to promote animal welfare. The registry is free of charge and is designed for exploratory and confirmatory studies within applied science as well as basic and preclinical research. The registration form helps scientists plan their study thoroughly by asking detailed questions concerning study design, methods, and statistics. With registration, the study automatically receives a digital object identifier (DOI) that marks it as intellectual property of the researcher. To accommodate the researchers concerns about theft of ideas, users can restrict the visibility of their registered studies for up to 5 years. The full content of the study becomes publicly accessible at the end of the embargo period. Because the platform is embedded in the infrastructure of the German Federal Government, continuity and data security are provided. By registering a study in the ASR, researchers can show their commitment to transparency and data quality to reviewers and editors, to third-party donors, and to the general public.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.