ArticleACS nano2019
Transient Photoinactivation of Cell Membrane Protein Activity without Genetic Modification by Molecular Hyperthermia.
Article in ACS nano, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Harnessing Dye-Induced Local Heating in Lipid Membranes: A Path to Near-Infrared Light-Modulated Artificial Synaptic Vesicles.ACS nano · 2025Article
- Regulating nanoscale directional heat transfer with Janus nanoparticles.Nanoscale advances · 2024Article
- Curvature and temperature-dependent thermal interface conductance between nanoscale gold and water.The Journal of chemical physics · 2022Article
- Single pulse heating of a nanoparticle array for biological applications.Nanoscale advances · 2022Article
- Spatiotemporal Evolution of Temperature During Transient Heating of Nanoparticle Arrays.Journal of heat transfer · 2022Article
- Nanoparticle Fragmentation Below the Melting Point Under Single Picosecond Laser Pulse Stimulation.The journal of physical chemistry. C, Nanomaterials and interfaces · 2021Article
- Gold nanoparticles alleviates the lipopolysaccharide-induced intestinal epithelial barrier dysfunction.Bioengineered · 2021Article
- Reversibly Modulating the Blood-Brain Barrier by Laser Stimulation of Molecular-Targeted Nanoparticles.Nano letters · 2021Article
- Nanotransducers for Wireless Neuromodulation.Matter · 2021Article
- Computational Investigation of Protein Photoinactivation by Molecular Hyperthermia.Journal of biomechanical engineering · 2021Article
- Non-Arrhenius Reaction-Diffusion Kinetics for Protein Inactivation over a Large Temperature Range.ACS nano · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Precise manipulation of protein activity in living systems has broad applications in biomedical sciences. However, it is challenging to use light to manipulate protein activity in living systems without genetic modification. Here, we report a technique to optically switch off protein activity in living cells with high spatiotemporal resolution, referred to as molecular hyperthermia (MH). MH is based on the nanoscale-confined heating of plasmonic gold nanoparticles by short laser pulses to unfold and photoinactivate targeted proteins of interest. First, we show that protease-activated receptor 2 (PAR2), a G-protein-coupled receptor and an important pathway that leads to pain sensitization, can be photoinactivated
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.