Trial reportThe New England journal of medicine2020
Conservative Oxygen Therapy during Mechanical Ventilation in the ICU.
5 registry-linked trialsOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in The New England journal of medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 207 papers, 17 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
207citing papers in PubMed, 17 pooled it
48.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Multicentre Observational Study on the Incidence of Hyperoxia in Non-intubated Patients in Intensive Care in Belgium Study OxSIZgen
Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients (SAVE-O2)
NCT04534972 phase3active not recruitingnot on this mapstarted 2021, after this paper: background citation
Strategy to Avoid Excessive Oxygen in Major Burn Patients (SAVE-O2)
Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients
NCT07536984 naenrolling by invitationnot on this mapstarted 2026, after this paper: background citation
Examination of Personalized SpO2 Targets
Who cites it
207 citing papers in PubMed, 17 syntheses or guidelines pooled it, 507 citations in OpenAlex.
- Relationship Between Cerebral Oximetry and Outcomes in Post-Cardiac Arrest Patients: A Systematic Review and Meta-Analysis.Critical care explorations · 2026Pooled it
- Conservative Oxygen Targets in Mechanically Ventilated Patients (OXY-BREATHES): A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Critical care medicine · 2026Pooled it
- Conservative versus liberal oxygen therapy for mechanically ventilated patients: a systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2026Pooled it
- Eligibility Criteria of Randomized Clinical Trials in Critical Care Medicine.JAMA network open · 2025Pooled it
- Conservative versus liberal oxygen therapy in mechanically ventilated patients: A systematic review with meta-analysis.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2025Pooled it
- Lower or higher oxygenation targets in the intensive care unit: an individual patient data meta-analysis.Intensive care medicine · 2024Pooled it
- Restrictive versus high-dose oxygenation strategy in post-arrest management following adult non-traumatic cardiac arrest: a meta-analysis.Critical care (London, England) · 2023Pooled it
- The effect of high perioperative inspiratory oxygen fraction for abdominal surgery on surgical site infection: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Higher versus lower fractions of inspired oxygen or targets of arterial oxygenation for adults admitted to the intensive care unit.The Cochrane database of systematic reviews · 2023Pooled it
- Sample size estimation in clinical trials using ventilator-free days as the primary outcome: a systematic review.Critical care (London, England) · 2023Pooled it
- Effects of Conservative Oxygen Therapy versus Conventional Oxygen Therapy on the Mortality in ICU Patients: A Meta-Analysis.Canadian respiratory journal · 2023Pooled it
- Long-term effects of lower versus higher oxygenation levels in adult ICU patients-A systematic review.Acta anaesthesiologica Scandinavica · 2022Pooled it
- [Oxygen in the acute care of adults : Short version of the German S3 guideline].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2022Guideline
- Liberal or conservative oxygen therapy for ventilated patients in the ICU: a meta-analysis of randomized controlled trials.Journal of cardiothoracic surgery · 2021Pooled it
- 2020 Korean Guidelines for Cardiopulmonary Resuscitation. Part 5. Post-cardiac arrest care.Clinical and experimental emergency medicine · 2021Guideline
- 2020 Korean Guidelines for Cardiopulmonary Resuscitation. Part 4. Adult advanced life support.Clinical and experimental emergency medicine · 2021Guideline
- The Effect of Conservative Oxygen Therapy in Reducing Mortality in Critical Care Patients: A Meta-Analysis and Trial Sequential Analysis.Frontiers in medicine · 2021Pooled it
- Effects of inhaled nitric oxide on ventilation/perfusion mismatch assessed by electrical impedance tomography in intubated patients with moderate-to-severe ARDS: a prospective physiological study.Respiratory research · 2026Trial
- Trial
- Effect of targeting normoxemia on supplemental oxygen-free days for adults with acute thermal burns: A stepped wedge cluster randomized clinical trial.The journal of trauma and acute care surgery · 2025Trial
147 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 1 institution in 1 country.
ICU-ROX Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group
Diane MackleFrom the Medical Research Institute of New Zealand (D.M., R. Beasley, R.F., C.M., S.M., P.Y.) and the Intensive Care Unit, Wellington Hospital (P.Y.), Wellington, the Intensive Care Unit, Hawkes Bay Hospital, Hastings (R.F.), and the Department of Critical Care Medicine (C.M.) and the Cardiothoracic and Vascular Intensive Care Unit (S.M.), Auckland City Hospital, Auckland - all in New Zealand; the Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC (R. Bellomo, M.B., V.K., N.L.), the Intensive Care Unit, Austin Hospital, Heidelberg, VIC (R. Bellomo, G.E.), the University of Melbourne (R. Bellomo, M.B., A.D.) and the Intensive Care Unit, Royal Melbourne Hospital (A.D.), Parkville, VIC, the Division of Critical Care and Trauma, George Institute for Global Health, Sydney (S.F.), the Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St. Leonards, NSW (S.F.), the Intensive Care Unit, Fiona Stanley Hospital, Murdoch, WA (E.L.), the Intensive Care Unit, John Hunter Hospital, New Lambton Heights, NSW (R.P.), and the School of Medicine and Public Health, University of Newcastle, Newcastle, NSW (R.P.) - all in Australia.
Rinaldo BellomoFrom the Medical Research Institute of New Zealand (D.M., R. Beasley, R.F., C.M., S.M., P.Y.) and the Intensive Care Unit, Wellington Hospital (P.Y.), Wellington, the Intensive Care Unit, Hawkes Bay Hospital, Hastings (R.F.), and the Department of Critical Care Medicine (C.M.) and the Cardiothoracic and Vascular Intensive Care Unit (S.M.), Auckland City Hospital, Auckland - all in New Zealand; the Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC (R. Bellomo, M.B., V.K., N.L.), the Intensive Care Unit, Austin Hospital, Heidelberg, VIC (R. Bellomo, G.E.), the University of Melbourne (R. Bellomo, M.B., A.D.) and the Intensive Care Unit, Royal Melbourne Hospital (A.D.), Parkville, VIC, the Division of Critical Care and Trauma, George Institute for Global Health, Sydney (S.F.), the Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St. Leonards, NSW (S.F.), the Intensive Care Unit, Fiona Stanley Hospital, Murdoch, WA (E.L.), the Intensive Care Unit, John Hunter Hospital, New Lambton Heights, NSW (R.P.), and the School of Medicine and Public Health, University of Newcastle, Newcastle, NSW (R.P.) - all in Australia.
Michael BaileyFrom the Medical Research Institute of New Zealand (D.M., R. Beasley, R.F., C.M., S.M., P.Y.) and the Intensive Care Unit, Wellington Hospital (P.Y.), Wellington, the Intensive Care Unit, Hawkes Bay Hospital, Hastings (R.F.), and the Department of Critical Care Medicine (C.M.) and the Cardiothoracic and Vascular Intensive Care Unit (S.M.), Auckland City Hospital, Auckland - all in New Zealand; the Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC (R. Bellomo, M.B., V.K., N.L.), the Intensive Care Unit, Austin Hospital, Heidelberg, VIC (R. Bellomo, G.E.), the University of Melbourne (R. Bellomo, M.B., A.D.) and the Intensive Care Unit, Royal Melbourne Hospital (A.D.), Parkville, VIC, the Division of Critical Care and Trauma, George Institute for Global Health, Sydney (S.F.), the Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St. Leonards, NSW (S.F.), the Intensive Care Unit, Fiona Stanley Hospital, Murdoch, WA (E.L.), the Intensive Care Unit, John Hunter Hospital, New Lambton Heights, NSW (R.P.), and the School of Medicine and Public Health, University of Newcastle, Newcastle, NSW (R.P.) - all in Australia.
Richard BeasleyFrom the Medical Research Institute of New Zealand (D.M., R. Beasley, R.F., C.M., S.M., P.Y.) and the Intensive Care Unit, Wellington Hospital (P.Y.), Wellington, the Intensive Care Unit, Hawkes Bay Hospital, Hastings (R.F.), and the Department of Critical Care Medicine (C.M.) and the Cardiothoracic and Vascular Intensive Care Unit (S.M.), Auckland City Hospital, Auckland - all in New Zealand; the Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC (R. Bellomo, M.B., V.K., N.L.), the Intensive Care Unit, Austin Hospital, Heidelberg, VIC (R. Bellomo, G.E.), the University of Melbourne (R. Bellomo, M.B., A.D.) and the Intensive Care Unit, Royal Melbourne Hospital (A.D.), Parkville, VIC, the Division of Critical Care and Trauma, George Institute for Global Health, Sydney (S.F.), the Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St. Leonards, NSW (S.F.), the Intensive Care Unit, Fiona Stanley Hospital, Murdoch, WA (E.L.), the Intensive Care Unit, John Hunter Hospital, New Lambton Heights, NSW (R.P.), and the School of Medicine and Public Health, University of Newcastle, Newcastle, NSW (R.P.) - all in Australia.ORCID 0000-0003-0337-406X
Adam DeaneFrom the Medical Research Institute of New Zealand (D.M., R. Beasley, R.F., C.M., S.M., P.Y.) and the Intensive Care Unit, Wellington Hospital (P.Y.), Wellington, the Intensive Care Unit, Hawkes Bay Hospital, Hastings (R.F.), and the Department of Critical Care Medicine (C.M.) and the Cardiothoracic and Vascular Intensive Care Unit (S.M.), Auckland City Hospital, Auckland - all in New Zealand; the Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC (R. Bellomo, M.B., V.K., N.L.), the Intensive Care Unit, Austin Hospital, Heidelberg, VIC (R. Bellomo, G.E.), the University of Melbourne (R. Bellomo, M.B., A.D.) and the Intensive Care Unit, Royal Melbourne Hospital (A.D.), Parkville, VIC, the Division of Critical Care and Trauma, George Institute for Global Health, Sydney (S.F.), the Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St. Leonards, NSW (S.F.), the Intensive Care Unit, Fiona Stanley Hospital, Murdoch, WA (E.L.), the Intensive Care Unit, John Hunter Hospital, New Lambton Heights, NSW (R.P.), and the School of Medicine and Public Health, University of Newcastle, Newcastle, NSW (R.P.) - all in Australia.
Glenn EastwoodFrom the Medical Research Institute of New Zealand (D.M., R. Beasley, R.F., C.M., S.M., P.Y.) and the Intensive Care Unit, Wellington Hospital (P.Y.), Wellington, the Intensive Care Unit, Hawkes Bay Hospital, Hastings (R.F.), and the Department of Critical Care Medicine (C.M.) and the Cardiothoracic and Vascular Intensive Care Unit (S.M.), Auckland City Hospital, Auckland - all in New Zealand; the Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC (R. Bellomo, M.B., V.K., N.L.), the Intensive Care Unit, Austin Hospital, Heidelberg, VIC (R. Bellomo, G.E.), the University of Melbourne (R. Bellomo, M.B., A.D.) and the Intensive Care Unit, Royal Melbourne Hospital (A.D.), Parkville, VIC, the Division of Critical Care and Trauma, George Institute for Global Health, Sydney (S.F.), the Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St. Leonards, NSW (S.F.), the Intensive Care Unit, Fiona Stanley Hospital, Murdoch, WA (E.L.), the Intensive Care Unit, John Hunter Hospital, New Lambton Heights, NSW (R.P.), and the School of Medicine and Public Health, University of Newcastle, Newcastle, NSW (R.P.) - all in Australia.
Simon FinferFrom the Medical Research Institute of New Zealand (D.M., R. Beasley, R.F., C.M., S.M., P.Y.) and the Intensive Care Unit, Wellington Hospital (P.Y.), Wellington, the Intensive Care Unit, Hawkes Bay Hospital, Hastings (R.F.), and the Department of Critical Care Medicine (C.M.) and the Cardiothoracic and Vascular Intensive Care Unit (S.M.), Auckland City Hospital, Auckland - all in New Zealand; the Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC (R. Bellomo, M.B., V.K., N.L.), the Intensive Care Unit, Austin Hospital, Heidelberg, VIC (R. Bellomo, G.E.), the University of Melbourne (R. Bellomo, M.B., A.D.) and the Intensive Care Unit, Royal Melbourne Hospital (A.D.), Parkville, VIC, the Division of Critical Care and Trauma, George Institute for Global Health, Sydney (S.F.), the Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St. Leonards, NSW (S.F.), the Intensive Care Unit, Fiona Stanley Hospital, Murdoch, WA (E.L.), the Intensive Care Unit, John Hunter Hospital, New Lambton Heights, NSW (R.P.), and the School of Medicine and Public Health, University of Newcastle, Newcastle, NSW (R.P.) - all in Australia.
Ross FreebairnFrom the Medical Research Institute of New Zealand (D.M., R. Beasley, R.F., C.M., S.M., P.Y.) and the Intensive Care Unit, Wellington Hospital (P.Y.), Wellington, the Intensive Care Unit, Hawkes Bay Hospital, Hastings (R.F.), and the Department of Critical Care Medicine (C.M.) and the Cardiothoracic and Vascular Intensive Care Unit (S.M.), Auckland City Hospital, Auckland - all in New Zealand; the Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC (R. Bellomo, M.B., V.K., N.L.), the Intensive Care Unit, Austin Hospital, Heidelberg, VIC (R. Bellomo, G.E.), the University of Melbourne (R. Bellomo, M.B., A.D.) and the Intensive Care Unit, Royal Melbourne Hospital (A.D.), Parkville, VIC, the Division of Critical Care and Trauma, George Institute for Global Health, Sydney (S.F.), the Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St. Leonards, NSW (S.F.), the Intensive Care Unit, Fiona Stanley Hospital, Murdoch, WA (E.L.), the Intensive Care Unit, John Hunter Hospital, New Lambton Heights, NSW (R.P.), and the School of Medicine and Public Health, University of Newcastle, Newcastle, NSW (R.P.) - all in Australia.
Victoria KingFrom the Medical Research Institute of New Zealand (D.M., R. Beasley, R.F., C.M., S.M., P.Y.) and the Intensive Care Unit, Wellington Hospital (P.Y.), Wellington, the Intensive Care Unit, Hawkes Bay Hospital, Hastings (R.F.), and the Department of Critical Care Medicine (C.M.) and the Cardiothoracic and Vascular Intensive Care Unit (S.M.), Auckland City Hospital, Auckland - all in New Zealand; the Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC (R. Bellomo, M.B., V.K., N.L.), the Intensive Care Unit, Austin Hospital, Heidelberg, VIC (R. Bellomo, G.E.), the University of Melbourne (R. Bellomo, M.B., A.D.) and the Intensive Care Unit, Royal Melbourne Hospital (A.D.), Parkville, VIC, the Division of Critical Care and Trauma, George Institute for Global Health, Sydney (S.F.), the Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St. Leonards, NSW (S.F.), the Intensive Care Unit, Fiona Stanley Hospital, Murdoch, WA (E.L.), the Intensive Care Unit, John Hunter Hospital, New Lambton Heights, NSW (R.P.), and the School of Medicine and Public Health, University of Newcastle, Newcastle, NSW (R.P.) - all in Australia.
Natalie LinkeFrom the Medical Research Institute of New Zealand (D.M., R. Beasley, R.F., C.M., S.M., P.Y.) and the Intensive Care Unit, Wellington Hospital (P.Y.), Wellington, the Intensive Care Unit, Hawkes Bay Hospital, Hastings (R.F.), and the Department of Critical Care Medicine (C.M.) and the Cardiothoracic and Vascular Intensive Care Unit (S.M.), Auckland City Hospital, Auckland - all in New Zealand; the Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC (R. Bellomo, M.B., V.K., N.L.), the Intensive Care Unit, Austin Hospital, Heidelberg, VIC (R. Bellomo, G.E.), the University of Melbourne (R. Bellomo, M.B., A.D.) and the Intensive Care Unit, Royal Melbourne Hospital (A.D.), Parkville, VIC, the Division of Critical Care and Trauma, George Institute for Global Health, Sydney (S.F.), the Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St. Leonards, NSW (S.F.), the Intensive Care Unit, Fiona Stanley Hospital, Murdoch, WA (E.L.), the Intensive Care Unit, John Hunter Hospital, New Lambton Heights, NSW (R.P.), and the School of Medicine and Public Health, University of Newcastle, Newcastle, NSW (R.P.) - all in Australia.
Edward LittonFrom the Medical Research Institute of New Zealand (D.M., R. Beasley, R.F., C.M., S.M., P.Y.) and the Intensive Care Unit, Wellington Hospital (P.Y.), Wellington, the Intensive Care Unit, Hawkes Bay Hospital, Hastings (R.F.), and the Department of Critical Care Medicine (C.M.) and the Cardiothoracic and Vascular Intensive Care Unit (S.M.), Auckland City Hospital, Auckland - all in New Zealand; the Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC (R. Bellomo, M.B., V.K., N.L.), the Intensive Care Unit, Austin Hospital, Heidelberg, VIC (R. Bellomo, G.E.), the University of Melbourne (R. Bellomo, M.B., A.D.) and the Intensive Care Unit, Royal Melbourne Hospital (A.D.), Parkville, VIC, the Division of Critical Care and Trauma, George Institute for Global Health, Sydney (S.F.), the Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St. Leonards, NSW (S.F.), the Intensive Care Unit, Fiona Stanley Hospital, Murdoch, WA (E.L.), the Intensive Care Unit, John Hunter Hospital, New Lambton Heights, NSW (R.P.), and the School of Medicine and Public Health, University of Newcastle, Newcastle, NSW (R.P.) - all in Australia.
Colin McArthurFrom the Medical Research Institute of New Zealand (D.M., R. Beasley, R.F., C.M., S.M., P.Y.) and the Intensive Care Unit, Wellington Hospital (P.Y.), Wellington, the Intensive Care Unit, Hawkes Bay Hospital, Hastings (R.F.), and the Department of Critical Care Medicine (C.M.) and the Cardiothoracic and Vascular Intensive Care Unit (S.M.), Auckland City Hospital, Auckland - all in New Zealand; the Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC (R. Bellomo, M.B., V.K., N.L.), the Intensive Care Unit, Austin Hospital, Heidelberg, VIC (R. Bellomo, G.E.), the University of Melbourne (R. Bellomo, M.B., A.D.) and the Intensive Care Unit, Royal Melbourne Hospital (A.D.), Parkville, VIC, the Division of Critical Care and Trauma, George Institute for Global Health, Sydney (S.F.), the Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St. Leonards, NSW (S.F.), the Intensive Care Unit, Fiona Stanley Hospital, Murdoch, WA (E.L.), the Intensive Care Unit, John Hunter Hospital, New Lambton Heights, NSW (R.P.), and the School of Medicine and Public Health, University of Newcastle, Newcastle, NSW (R.P.) - all in Australia.
Shay McGuinnessFrom the Medical Research Institute of New Zealand (D.M., R. Beasley, R.F., C.M., S.M., P.Y.) and the Intensive Care Unit, Wellington Hospital (P.Y.), Wellington, the Intensive Care Unit, Hawkes Bay Hospital, Hastings (R.F.), and the Department of Critical Care Medicine (C.M.) and the Cardiothoracic and Vascular Intensive Care Unit (S.M.), Auckland City Hospital, Auckland - all in New Zealand; the Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC (R. Bellomo, M.B., V.K., N.L.), the Intensive Care Unit, Austin Hospital, Heidelberg, VIC (R. Bellomo, G.E.), the University of Melbourne (R. Bellomo, M.B., A.D.) and the Intensive Care Unit, Royal Melbourne Hospital (A.D.), Parkville, VIC, the Division of Critical Care and Trauma, George Institute for Global Health, Sydney (S.F.), the Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St. Leonards, NSW (S.F.), the Intensive Care Unit, Fiona Stanley Hospital, Murdoch, WA (E.L.), the Intensive Care Unit, John Hunter Hospital, New Lambton Heights, NSW (R.P.), and the School of Medicine and Public Health, University of Newcastle, Newcastle, NSW (R.P.) - all in Australia.
Rakshit PanwarFrom the Medical Research Institute of New Zealand (D.M., R. Beasley, R.F., C.M., S.M., P.Y.) and the Intensive Care Unit, Wellington Hospital (P.Y.), Wellington, the Intensive Care Unit, Hawkes Bay Hospital, Hastings (R.F.), and the Department of Critical Care Medicine (C.M.) and the Cardiothoracic and Vascular Intensive Care Unit (S.M.), Auckland City Hospital, Auckland - all in New Zealand; the Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC (R. Bellomo, M.B., V.K., N.L.), the Intensive Care Unit, Austin Hospital, Heidelberg, VIC (R. Bellomo, G.E.), the University of Melbourne (R. Bellomo, M.B., A.D.) and the Intensive Care Unit, Royal Melbourne Hospital (A.D.), Parkville, VIC, the Division of Critical Care and Trauma, George Institute for Global Health, Sydney (S.F.), the Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St. Leonards, NSW (S.F.), the Intensive Care Unit, Fiona Stanley Hospital, Murdoch, WA (E.L.), the Intensive Care Unit, John Hunter Hospital, New Lambton Heights, NSW (R.P.), and the School of Medicine and Public Health, University of Newcastle, Newcastle, NSW (R.P.) - all in Australia.
Paul YoungFrom the Medical Research Institute of New Zealand (D.M., R. Beasley, R.F., C.M., S.M., P.Y.) and the Intensive Care Unit, Wellington Hospital (P.Y.), Wellington, the Intensive Care Unit, Hawkes Bay Hospital, Hastings (R.F.), and the Department of Critical Care Medicine (C.M.) and the Cardiothoracic and Vascular Intensive Care Unit (S.M.), Auckland City Hospital, Auckland - all in New Zealand; the Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC (R. Bellomo, M.B., V.K., N.L.), the Intensive Care Unit, Austin Hospital, Heidelberg, VIC (R. Bellomo, G.E.), the University of Melbourne (R. Bellomo, M.B., A.D.) and the Intensive Care Unit, Royal Melbourne Hospital (A.D.), Parkville, VIC, the Division of Critical Care and Trauma, George Institute for Global Health, Sydney (S.F.), the Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St. Leonards, NSW (S.F.), the Intensive Care Unit, Fiona Stanley Hospital, Murdoch, WA (E.L.), the Intensive Care Unit, John Hunter Hospital, New Lambton Heights, NSW (R.P.), and the School of Medicine and Public Health, University of Newcastle, Newcastle, NSW (R.P.) - all in Australia.ORCID 0000-0002-3428-3083
ICU-ROX Investigators the Australian and New Zealand Intensive Care Society Clinical Trials Group
Intensive Care Society · GB
Funding
Health Research Council of New Zealand 16/014
Abstract
backgroundPatients who are undergoing mechanical ventilation in the intensive care unit (ICU) often receive a high fraction of inspired oxygen (Fio
methodsWe randomly assigned 1000 adult patients who were anticipated to require mechanical ventilation beyond the day after recruitment in the ICU to receive conservative or usual oxygen therapy. In the two groups, the default lower limit for oxygen saturation as measured by pulse oximetry (Spo
resultsThe number of ventilator-free days did not differ significantly between the conservative-oxygen group and the usual-oxygen group, with a median duration of 21.3 days (interquartile range, 0 to 26.3) and 22.1 days (interquartile range, 0 to 26.2), respectively, for an absolute difference of -0.3 days (95% confidence interval [CI], -2.1 to 1.6; P = 0.80). The conservative-oxygen group spent more time in the ICU with an Fio
conclusionsIn adults undergoing mechanical ventilation in the ICU, the use of conservative oxygen therapy, as compared with usual oxygen therapy, did not significantly affect the number of ventilator-free days. (Funded by the Health Research Council of New Zealand; ICU-ROX Australian and New Zealand Clinical Trials Registry number, ACTRN12615000957594.).
Indexed as
Oxygen Inhalation TherapyRespiration, ArtificialAdultAgedConservative TreatmentFemaleHumansIntensive Care UnitsMaleMiddle AgedOxygenTreatment OutcomeVentilator WeaningOxygen
Identifiers
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Registered trials
NCT04291911ClinicalTrials.gov
NCT04534959ClinicalTrials.gov
NCT04534972ClinicalTrials.gov
NCT06501118ClinicalTrials.gov
NCT07536984ClinicalTrials.gov
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