Evidence map›Paper›PMID 31613223›Full record

ArticleeLife2019

Neuron-specific knockouts indicate the importance of network communication to

Matthias Schlichting, Madelen M Díaz, Jason Xin, Michael Rosbash

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 91 citations in OpenAlex.

  1. Journal of biological rhythms · 2026
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  6. Journal of biological rhythms · 2025
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  7. A functional clock in only two dorsal clock neurons is sufficient to restore the basal circadian activity pattern ofProceedings of the National Academy of Sciences of the United States of America · 2025
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  19. Timeless noncoding DNA contains cell-type preferential enhancers important for proper Drosophila circadian regulation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Matthias SchlichtingDepartment of Biology, Howard Hughes Medical Institute, Brandeis University, Waltham, United States.ORCID 0000-0002-0822-0265
Madelen M DíazDepartment of Biology, Howard Hughes Medical Institute, Brandeis University, Waltham, United States.
Jason XinDepartment of Biology, Howard Hughes Medical Institute, Brandeis University, Waltham, United States.
Michael RosbashDepartment of Biology, Howard Hughes Medical Institute, Brandeis University, Waltham, United States.ORCID 0000-0003-3366-1780
Howard Hughes Medical Institute · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
NEUROSCIENCE: FROM CHANNELS TO BEHAVIORT32MH019929 · NIMH · BRANDEIS UNIVERSITY · PI GRIFFITH, LESLIE C · 1994 to 2023
$8.5M
NIH HHS P40 OD018537NIMH NIH HHS T32 MH019929
6 · The paper itself

Abstract

Animal circadian rhythms persist in constant darkness and are driven by intracellular transcription-translation feedback loops. Although these cellular oscillators communicate, isolated mammalian cellular clocks continue to tick away in darkness without intercellular communication. To investigate these issues in

Indexed as

Gene Expression RegulationAnimalsBasic-Leucine Zipper Transcription FactorsBrainCell CommunicationCell LineageCircadian ClocksCircadian RhythmCRISPR-Cas SystemsDarknessDrosophila melanogasterDrosophila ProteinsFeedback, PhysiologicalGene EditingLight Signal TransductionNerve NetBasic-Leucine Zipper Transcription FactorsDrosophila ProteinsGAL4 protein, DrosophilaNeuropeptidespdf protein, DrosophilaPDP1 protein, DrosophilaPeriod Circadian ProteinsPER protein, Drosophilatim protein, DrosophilaTranscription Factorsactivitycircadian rhythmD. melanogasternetwork communicationneuroscience

Identifiers

PMID31613223
PMCPMC6794074
OpenAlexW2980464469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.