ArticleBiotechnology and bioengineering2020
Ultrahigh-cell-density heterotrophic cultivation of the unicellular green microalga Scenedesmus acuminatus and application of the cells to photoautotrophic culture enhance biomass and lipid production.
Article in Biotechnology and bioengineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 117 citations in OpenAlex.
- Microalgae as a sustainable alternative to palm oil: fatty acid profiles under photoautotrophic and heterotrophic growth.Applied microbiology and biotechnology · 2026Article
- Application of Cyanobacteria as Chassis Cells in Synthetic Biology.Microorganisms · 2024Review
- Biotechnologies for bulk production of microalgal biomass: from mass cultivation to dried biomass acquisition.Biotechnology for biofuels and bioproducts · 2023Review
- Article
- Enhanced Carotenoid Production inInternational journal of molecular sciences · 2023Article
- Optimization of Heterotrophic Culture Conditions for the AlgaePlants (Basel, Switzerland) · 2023Article
- Microalgal polyunsaturated fatty acids: Hotspots and production techniques.Frontiers in bioengineering and biotechnology · 2023Review
- Application of microalgaeFrontiers in bioengineering and biotechnology · 2023Article
- Biotechnological production of omega-3 fatty acids: current status and future perspectives.Frontiers in microbiology · 2023Review
- Development of Microalgae Biodiesel: Current Status and Perspectives.Microorganisms · 2022Review
- Effects of Chlorella extracts on growth of Capsicum annuum L. seedlings.Scientific reports · 2022Article
- Mixotrophic Cultivation Optimization of MicroalgaMarine drugs · 2022Article
- Effective fucoxanthin production in the flagellate algaFrontiers in bioengineering and biotechnology · 2022Article
- Effective Two-Stage Heterotrophic Cultivation of the Unicellular Green MicroalgaFrontiers in bioengineering and biotechnology · 2022Article
- Heterotrophically Ultrahigh-Cell-Density Cultivation of a High Protein-Yielding Unicellular AlgaFrontiers in bioengineering and biotechnology · 2021Article
- Trophic Transition Enhanced Biomass and Lipid Production of the Unicellular Green AlgaFrontiers in bioengineering and biotechnology · 2021Article
- Ultrahigh-cell-density heterotrophic cultivation of the unicellular green microalga Scenedesmus acuminatus and application of the cells to photoautotrophic culture enhance biomass and lipid production.Biotechnology and bioengineering · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
Although production of biodiesels from microalgae is proved to be technically feasible, a commercially viable system has yet to emerge. High-cell-density fermentation of microalgae can be coupled with photoautotrophic cultivation to produce oils. In this study, by optimizing culturing conditions and employing a sophisticated substrate feed control strategy, ultrahigh-cell-density of 286 and 283.5 g/L was achieved for the unicellular alga Scenedesmus acuminatus grown in 7.5-L bench-scale and 1,000-L pilot-scale fermenters, respectively. The outdoor scale-up experiments indicated that heterotrophically grown S. acuminatus cells are more productive in terms of both biomass and lipid accumulation when they are inoculated in photobioreactors for lipid production as compared to the cells originally grown under photoautotrophic conditions. Technoeconomic analysis based on the pilot-scale data indicated that the cost of heterotrophic cultivation of microalgae for biomass production is comparable with that of the open-pond system and much lower than that of tubular PBR, if the biomass yield was higher than 200 g/L. This study demonstrated the economic viability of heterotrophic cultivation on large-scale microalgal inocula production, but ultrahigh-productivity fermentation is a prerequisite. Moreover, the advantages of the combined heterotrophic and photoautotrophic cultivation of microalgae for biofuels production were also verified in the pilot-scale.
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