Evidence map›Paper›PMID 31612990›Full record

ArticleBiotechnology and bioengineering2020

Survival of aging CD264

Sean D Madsen, Sean H Jones, H Alan Tucker, Margaret K Giler, Dyllan C Muller, Carson T Discher, Katie C Russell, Georgina L Dobek, Mimi C Sammarco, Bruce A Bunnell and 1 more

Open access · greenAbstract read
In one paragraph

Article in Biotechnology and bioengineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. RNA sequencing identifiesCytotechnology · 2025
    Article
  2. Protocols to Assess the Aging of Human Mesenchymal Stem Cells.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Sean D MadsenDepartment of Chemical and Biomolecular Engineering, School of Science and Engineering, Tulane University, New Orleans, Louisiana.
Sean H JonesDepartment of Comparative Medicine, School of Medicine, Tulane University, New Orleans, Louisiana.
H Alan TuckerCenter for Stem Cell Research and Regenerative Medicine, School of Medicine, Tulane University, New Orleans, Louisiana.
Margaret K GilerDepartment of Chemical and Biomolecular Engineering, School of Science and Engineering, Tulane University, New Orleans, Louisiana.
Dyllan C MullerDepartment of Chemical and Biomolecular Engineering, School of Science and Engineering, Tulane University, New Orleans, Louisiana.
Carson T DischerDepartment of Chemical and Biomolecular Engineering, School of Science and Engineering, Tulane University, New Orleans, Louisiana.
Katie C RussellDepartment of Chemical and Biomolecular Engineering, School of Science and Engineering, Tulane University, New Orleans, Louisiana.
Georgina L DobekDepartment of Comparative Medicine, School of Medicine, Tulane University, New Orleans, Louisiana.
Mimi C SammarcoCenter for Stem Cell Research and Regenerative Medicine, School of Medicine, Tulane University, New Orleans, Louisiana.
Bruce A BunnellCenter for Stem Cell Research and Regenerative Medicine, School of Medicine, Tulane University, New Orleans, Louisiana.
Kim C O'ConnorDepartment of Chemical and Biomolecular Engineering, School of Science and Engineering, Tulane University, New Orleans, Louisiana.ORCID 0000-0003-4030-3957
Tulane University · US

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
Division of Chemical, Bioengineering, Environmental, and Transport SystemsNational Science Foundation CBET-1604129NIH HHS P51 OD011104
6 · The paper itself

Abstract

In vivo mesenchymal stem cell (MSC) survival is relevant to therapeutic applications requiring engraftment and potentially to nonengraftment applications as well. MSCs are a mixture of progenitors at different stages of cellular aging, but the contribution of this heterogeneity to the survival of MSC implants is unknown. Here, we employ a biomarker of cellular aging, the decoy TRAIL receptor CD264, to compare the survival kinetics of two cell populations in human bone marrow MSC (hBM-MSC) cultures. Sorted CD264

Indexed as

Mesenchymal Stem CellsAdultAnimalsCell DifferentiationCells, CulturedCell SurvivalCellular SenescenceFemaleHumansMaleMiceReceptors, TNF-Related Apoptosis-Inducing LigandReceptors, TNF-Related Apoptosis-Inducing Ligandagingdecoy TRAIL receptor 2 (CD264)mesenchymal stem cellssurvival

Identifiers

PMID31612990
PMCPMC6906265
OpenAlexW2981090210

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.