ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2019
A Biohistorical Perspective of Typhoid and Antimicrobial Resistance.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Evaluation of Two Naturally Occurring Phytochemicals, 6‑Methoxy-2-benzoxazolinone and 2‑Benzoxazolinone, against Drug-ResistantACS omega · 2026Article
- Integrative genomic and molecular dynamics characterisation ofFrontiers in microbiology · 2026Article
- XDR typhoid in Pakistan: A threat to global health security and a wake-up call for antimicrobial stewardship.PLoS neglected tropical diseases · 2025Article
- Imported Typhoid Fever in Romania Between 2010 and 2024.Infectious disease reports · 2025Article
- Emergence of carbapenem-resistantFrontiers in microbiology · 2025Article
- Estimating the subnational prevalence of antimicrobial resistant Salmonella enterica serovars Typhi and Paratyphi A infections in 75 endemic countries, 1990-2019: a modelling study.The Lancet. Global health · 2024Article
- Assessing the global risk of typhoid outbreaks caused by extensively drug resistant Salmonella Typhi.Nature communications · 2023Article
- Typhoid Control in an Era of Antimicrobial Resistance: Challenges and Opportunities.Open forum infectious diseases · 2023Article
- Article
- Understanding antibiotic use: practices, structures and networks.JAC-antimicrobial resistance · 2021Review
- Waves of attention: patterns and themes of international antimicrobial resistance reports, 1945-2020.BMJ global health · 2021Article
- Salmonella Typhi acquires diverse plasmids from other Enterobacteriaceae to develop cephalosporin resistance.Genomics · 2021Article
- Antimicrobial Resistance in Typhoidal Salmonella: Surveillance for Enteric Fever in Asia Project, 2016-2019.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Setting the standard: multidisciplinary hallmarks for structural, equitable and tracked antibiotic policy.BMJ global health · 2020Review
- Toward Control? The Prospects and Challenges of Typhoid Conjugate Vaccine Introduction.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
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Authors and funding
3 authors.
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Abstract
We combine methodology from history and genetics to reconstruct the biosocial history of antimicrobial resistance (AMR) in the bacterium Salmonella enterica serovar Typhi (S. Typhi). We show how evolutionary divergence in S. Typhi was driven by rising global antibiotic use and by the neglect of typhoid outside of high-income countries. Although high-income countries pioneered 1960s precautionary antibiotic regulations to prevent selection for multidrug resistance, new antibiotic classes, typhoid's cultural status as a supposedly ancient disease of "undeveloped" countries, limited international funding, and narrow biosecurity agendas helped fragment effective global collective action for typhoid control. Antibiotic-intensive compensation for weak water and healthcare systems subsequently fueled AMR selection in low- and middle-income countries but often remained invisible due to lacking surveillance capabilities. The recent rise of extensively drug-resistant typhoid bears the biosocial footprint of more than half a century of antibiotic-intensive international neglect.
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Registered trials
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