ArticleAdvances in nutrition (Bethesda, Md.)2020
Perspective: Human Milk Oligosaccharides: Fuel for Childhood Obesity Prevention?
Article in Advances in nutrition (Bethesda, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Trial
- Maternal obesity alters human milk oligosaccharides content and correlates with early acquisition of late colonizers in the neonatal gut microbiome.Gut microbes · 2026Article
- Human milk oligosaccharide supplementation for metabolic health and obesity: potential mechanisms, current evidence, and research priorities.World journal of pediatrics : WJP · 2026Article
- Phosphatidylethanolamine/PKA signal axis mediated human milk extracellular vesicles enhance adipose thermogenesis and lipolysis via mitochondrial remodeling.International journal of obesity (2005) · 2025Article
- Using Gut Microbiota Modulation as a Precision Strategy Against Obesity.International journal of molecular sciences · 2025Review
- From Pregnancy to Breastfeeding: The Role of Maternal Exercise in Preventing Childhood Obesity.Nutrients · 2025Review
- Microbiota from human infants consuming secretors or non-secretors mothers' milk impacts the gut and immune system in mice.mSystems · 2024Article
- Research trends between childhood obesity and gut microbiota: a bibliometric analysis (2002-2023).Frontiers in microbiology · 2024Review
- Can prebiotics help tackle the childhood obesity epidemic?Frontiers in endocrinology · 2023Review
- The effects of breastfeeding and formula feeding on the metabolic factors and the expression level of obesity and diabetes-predisposing genes in healthy infants.Physiological reports · 2022Article
- Breastfeeding Associations with Childhood Obesity and Body Composition: Findings from a Racially Diverse Maternal-Child Cohort.Childhood obesity (Print) · 2022Article
- Concentrations of oligosaccharides in human milk and child growth.BMC pediatrics · 2021Article
- Article
- Early-life gut microbiota and its connection to metabolic health in children: Perspective on ecological drivers and need for quantitative approach.EBioMedicine · 2021Review
- The Triad Mother-Breast Milk-Infant as Predictor of Future Health: A Narrative Review.Nutrients · 2021Review
- Review
- Do Human Milk Oligosaccharides Protect Against Infant Atopic Disorders and Food Allergy?Nutrients · 2020Article
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Authors and funding
4 authors.
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Abstract
Obesity begins early but has lifelong consequences for health and well-being. Breastfeeding is thought to be preventive against obesity, but the extent and cause of this association are not well understood. Human milk oligosaccharides (HMOs) are abundant in human milk and not present in commercially available infant formula. These complex sugars are thought to contribute to the development of the infant gut microbiome and immune system. Recently, they have been investigated as a potential link between breastfeeding and lower obesity risk. So far, only a few human studies have examined HMO composition of human milk in association with the infant's concurrent anthropometry or subsequent growth in infancy, with conflicting results. However, HMOs have been shown to modulate the gut microbiome profile by selectively promoting the growth of specific bacteria, such as bifidobacteria. Moreover, there are differences in the gut microbiome of lean and obese humans, and there is some evidence that the early composition of the gut microbiome can predict later obesity. Although it seems that HMOs might have a role in infant growth and adiposity, there is not enough consistent evidence to understand their potential role in obesity prevention. More data, particularly from large or longitudinal studies, are needed to clarify the functions of HMOs and other breast-milk components in determining long-term health.
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