Evidence map›Paper›PMID 31612862›Full record

ArticleeLife2019

Electron transport chain biogenesis activated by a JNK-insulin-Myc relay primes mitochondrial inheritance in

Zong-Heng Wang, Yi Liu, Vijender Chaitankar, Mehdi Pirooznia, Hong Xu

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 49 citations in OpenAlex.

  1. Cytoplasmic fluidity couples nutrient availability and enterocyte fate in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Finishing the egg.Genetics · 2024
    Article
  8. MYC: there is more to it than cancer.Frontiers in cell and developmental biology · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Inducible SystemicInternational journal of molecular sciences · 2022
    Article
  17. Article
  18. Mitochondrial function in development and disease.Disease models & mechanisms · 2021
    Review
  19. Mitochondrial Respiration inCurrent issues in molecular biology · 2021
    Article
  20. Mitochondrial Control of Stem Cell State and Fate: Lessons FromFrontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zong-Heng WangNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, United States.
Yi LiuNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, United States.
Vijender ChaitankarNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, United States.
Mehdi PiroozniaNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, United States.
Hong XuNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, United States.ORCID 0000-0002-1423-1809
National Institutes of Health · US

Funding

Mitochondrial DNA inheritance in DrosophilaZIAHL006153 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI XU, HONG · 2012 to 2025
$26.5M
Intramural NIH HHS ZIA HL006153NHLBI NIH HHS 1ZIAHL006153-07NHLBI NIH HHS Project Number: 1ZIAHL006153-07
6 · The paper itself

Abstract

Oogenesis features an enormous increase in mitochondrial mass and mtDNA copy number, which are required to furnish mature eggs with an adequate supply of mitochondria and to curb the transmission of deleterious mtDNA variants. Quiescent in dividing germ cells, mtDNA replication initiates upon oocyte determination in the

Indexed as

Genes, MitochondrialAnimalsDNA-Binding ProteinsDrosophilaDrosophila ProteinsElectron Transport Chain Complex ProteinsInsulinMAP Kinase Kinase 4MitochondriaOrganelle BiogenesisReceptor Protein-Tyrosine KinasesSignal TransductionTranscription FactorsDNA-Binding ProteinsDrosophila ProteinsElectron Transport Chain Complex ProteinsInR protein, DrosophilaInsulinMAP Kinase Kinase 4Myc protein, DrosophilaReceptor Protein-Tyrosine KinasesTranscription Factorsdevelopmental biologyD. melanogasterinsulin signalingJNK signalingmitochondriamitochondrial inheritancemtDNAMyc

Identifiers

PMID31612862
PMCPMC6809605
OpenAlexW2981218333

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.