Evidence map›Paper›PMID 31612857›Full record

ArticleeLife2019

Evolutionary loss of foot muscle during development with characteristics of atrophy and no evidence of cell death.

Mai P Tran, Rio Tsutsumi, Joel M Erberich, Kevin D Chen, Michelle D Flores, Kimberly L Cooper

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mai P TranDivision of Biological Sciences, Section of Cellular and Developmental Biology, University of California, San Diego, La Jolla, United States.ORCID 0000-0001-7127-4947
Rio TsutsumiDivision of Biological Sciences, Section of Cellular and Developmental Biology, University of California, San Diego, La Jolla, United States.ORCID 0000-0001-9473-3923
Joel M ErberichDivision of Biological Sciences, Section of Cellular and Developmental Biology, University of California, San Diego, La Jolla, United States.
Kevin D ChenDivision of Biological Sciences, Section of Cellular and Developmental Biology, University of California, San Diego, La Jolla, United States.
Michelle D FloresDivision of Biological Sciences, Section of Cellular and Developmental Biology, University of California, San Diego, La Jolla, United States.
Kimberly L CooperDivision of Biological Sciences, Section of Cellular and Developmental Biology, University of California, San Diego, La Jolla, United States.ORCID 0000-0001-5892-8838
University of California San Diego · US

Funding

GENETIC MECHANISMS AND REGULATIONT32GM007240 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMPTON, RANDOLPH Y. · 1985 to 2019
$23.8M
IVEM and Image Analysis ResourceP41GM103412 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2012 to 2019
$17.9M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
An exploration of the mechanisms of naturally occurring limb muscle loss during neonatal developmentR21AR074609 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COOPER, KIMBERLY LYNN · 2019 to 2020
$369k
David and Lucile Packard Foundation Packard Fellowships in Science and EngineeringKinship Foundation Searle ScholarshipNIAMS NIH HHS R21 AR074609NIGMS NIH HHS P41 GM103412NIGMS NIH HHS T32 GM007240NIH HHS R21 AR074609-01A1NIH HHS T32GM724039NINDS NIH HHS P30 NS047101Pew Charitable Trusts Pew Biomedical Scholarship
6 · The paper itself

Abstract

Many species that run or leap across sparsely vegetated habitats, including horses and deer, evolved the severe reduction or complete loss of foot muscles as skeletal elements elongated and digits were lost, and yet the developmental mechanisms remain unknown. Here, we report the natural loss of foot muscles in the bipedal jerboa,

Indexed as

AtrophyAnimalsApoptosisFootMuscle CellsMuscle, SkeletalNecrosisRodentiaatrophycell deathdevelopmental biologyevolutionary biologyjerboalimbmousemuscle

Identifiers

PMID31612857
PMCPMC6855805
OpenAlexW2981271695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.