Effect and Mechanism of Phosphodiesterase Inhibitors on Trabecular Outflow.

Jae Woo Kim, Jong Been Lee, So Hyung Lee

Open access · goldAbstract read

In one paragraph

Article in Korean journal of ophthalmology : KJO, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 90% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jae Woo KimDepartment of Ophthalmology, Daegu Catholic University School of Medicine, Daegu, Korea. jwkim@cu.ac.kr.

Jong Been LeeDepartment of Ophthalmology, Daegu Catholic University School of Medicine, Daegu, Korea.

So Hyung LeeDepartment of Ophthalmology, Daegu Catholic University School of Medicine, Daegu, Korea.

Catholic University of Daegu · KR

Funding

Research Institute of Medical Science, Daegu Catholic University

6 · The paper itself

Abstract

purposePhosphodiesterase (PDE) inhibitors increase matrix metalloproteinase (MMP) production by inhibiting re-uptake of adenosine and may potentiate nitric oxide (NO) activity. This study was performed to investigate the effects and mechanisms of PDE inhibitors on trabecular outflow in cultured human trabecular meshwork cells (HTMCs).

methodsPrimary HTMC cultures were exposed to 0, 20, and 50 μM dipyridamole (DPD) or theophylline (TPN). Permeability through the HTMC monolayer was assessed using carboxyfluorescein. The production of NO was assessed using the Griess assay and MMP-2 levels were measured via Western blotting.

resultsDPD significantly increased permeability accompanied with increased nitrite concentration and MMP-2 levels (all

conclusionsDPD increased trabecular permeability accompanied with increased nitrite production and MMP-2 levels. PDE inhibitors may increase trabecular outflow by increasing MMP-2 levels and by potentiating NO activity through cyclic GMP in HTMC.

Indexed as

AdenosineBlotting, WesternCells, CulturedDipyridamoleHumansMatrix MetalloproteinasesNitric OxidePhosphodiesterase InhibitorsTheophyllineTrabecular MeshworkAdenosineDipyridamoleMatrix MetalloproteinasesNitric OxidePhosphodiesterase InhibitorsTheophyllineDipyridamoleMatrix metalloproteinasesNitric oxideTheophyllineTrabecular meshwork

Identifiers

PMID31612651

DOI10.3341/kjo.2019.0057

PMCPMC6791954

OpenAlexW2969450152

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.