Evidence map›Paper›PMID 31612463›Full record

ArticleJournal of the American Geriatrics Society2020

Development and Validation of eRADAR: A Tool Using EHR Data to Detect Unrecognized Dementia.

Deborah E Barnes, Jing Zhou, Rod L Walker, Eric B Larson, Sei J Lee, W John Boscardin, Zachary A Marcum, Sascha Dublin

3 registry-linked trialsOpen access · greenAbstract readValidation Study
In one paragraph

Article in Journal of the American Geriatrics Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 66 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 3 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04912245 nacompletednot on this mapstarted 2021, after this paper: background citation

A Telehealth Advance Care Planning Intervention in Those With Mild Cognitive Impairment or Unrecognized Dementia (Tele Voice)

TypeinterventionalSponsorWake Forest University Health SciencesRan2021 to 2022Enrolled152ConditionsAdvance Care Planning, Telemedicine, Mild Cognitive Impairment, Unrecognized DementiaArmsTelehealth visit
NCT05356702 nacompletednot on this mapstarted 2022, after this paper: background citation

Low-cost Detection of Dementia Using Electronic Health Records Data: Validation and Testing of the eRADAR Algorithm in a Pragmatic, Patient-centered Trial.

TypeinterventionalSponsorKaiser PermanenteRan2022 to 2026Enrolled3,417ConditionsDementia, Alzheimer DiseaseArmsBrain Health Assessment
NCT05905796 nacompletednot on this mapstarted 2022, after this paper: background citation

Low-cost Detection of Dementia Using Electronic Health Records Data: Validation and Testing of the Electronic Health Record Risk of Alzheimer's and Dementia Assessment Rule (eRADAR) Algorithm in a Pragmatic, Patient-centered Trial.

TypeinterventionalSponsorUniversity of California, San FranciscoRan2022 to 2026Enrolled1,271ConditionsDementia, Alzheimer DiseaseArmsBrain Health Assessment
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.

  1. Pooled it
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  8. Accelerating real-world prediction and research in Alzheimer's: The M3AD study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
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  15. The Impact of Cognitive Impairment on Cardiovascular Disease.Journal of the American College of Cardiology · 2025
    Review
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  20. Paving the way for Alzheimer's disease blood-based biomarkers in primary care.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Deborah E BarnesDepartment of Psychiatry, University of California, San Francisco, San Francisco, California.ORCID 0000-0002-2953-4079
Jing ZhouBiostatistics Unit, Kaiser Permanente Washington Health Research Institute, Seattle, Washington.
Rod L WalkerBiostatistics Unit, Kaiser Permanente Washington Health Research Institute, Seattle, Washington.
Eric B LarsonKaiser Permanente Washington Health Research Institute.
Sei J LeeSan Francisco Veterans Affairs Health Care System.
W John BoscardinDepartment of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, California.
Zachary A MarcumDepartment of Pharmacy, University of Washington, Seattle, Washington.ORCID 0000-0002-4690-2304
Sascha DublinKaiser Permanente Washington Health Research Institute.
Kaiser Permanente Washington Health Research Institute · USUniversity of California, San Francisco · USUniversity of Washington · US

Funding

Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
Advancing Geriatrics Infrastructure & Network Growth - Admin Supplement: Designing and Testing an Informatics Tool to Aid Prescribers in Reducing Anticholinergic Burden in Older AdultsR24AG045050 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GURWITZ, JERRY H · 2014 to 2017
$3.6M
Development and Validation of the EMR Risk of Alzheimer's and Dementia Assessment Rule (eRADAR)R56AG056417 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI BARNES, DEBORAH E. · 2017 to 2017
$793k
Antihypertensives and the Aging BrainK76AG059929 · NIA · UNIVERSITY OF WASHINGTON · PI MARCUM, ZACHARY ADAM · 2019 to 2021
$694k
AHRQ HHS K12 HS022982NIA NIH HHS K76 AG059929NIA NIH HHS R24 AG045050NIA NIH HHS R56 AG056417NIA NIH HHS U01 AG006781
6 · The paper itself

Abstract

objectivesEarly recognition of dementia would allow patients and their families to receive care earlier in the disease process, potentially improving care management and patient outcomes, yet nearly half of patients with dementia are undiagnosed. Our aim was to develop and validate an electronic health record (EHR)-based tool to help detect patients with unrecognized dementia (EHR Risk of Alzheimer's and Dementia Assessment Rule [eRADAR]).

designRetrospective cohort study.

settingKaiser Permanente Washington (KPWA), an integrated healthcare delivery system.

participantsA total of 16 665 visits among 4330 participants in the Adult Changes in Thought (ACT) study, who undergo a comprehensive process to detect and diagnose dementia every 2 years and have linked KPWA EHR data, divided into development (70%) and validation (30%) samples. MEASUREMENTS: EHR predictors included demographics, medical diagnoses, vital signs, healthcare utilization, and medications within the previous 2 years. Unrecognized dementia was defined as detection in ACT before documentation in the KPWA EHR (ie, lack of dementia or memory loss diagnosis codes or dementia medication fills).

resultsOverall, 1015 ACT visits resulted in a diagnosis of incident dementia, of which 498 (49%) were unrecognized in the KPWA EHR. The final 31-predictor model included markers of dementia-related symptoms (eg, psychosis diagnoses, antidepressant fills), healthcare utilization pattern (eg, emergency department visits), and dementia risk factors (eg, cerebrovascular disease, diabetes). Discrimination was good in the development (C statistic = .78; 95% confidence interval [CI] = .76-.81) and validation (C statistic = .81; 95% CI = .78-.84) samples, and calibration was good based on plots of predicted vs observed risk. If patients with scores in the top 5% were flagged for additional evaluation, we estimate that 1 in 6 would have dementia.

conclusionThe eRADAR tool uses existing EHR data to detect patients with good accuracy who may have unrecognized dementia. J Am Geriatr Soc 68:103-111, 2019.

Indexed as

Decision Support TechniquesEarly DiagnosisAged, 80 and overAntidepressive AgentsCerebrovascular DisordersDelivery of Health Care, IntegratedDementiaDiabetes MellitusDrug MonitoringElectronic Health RecordsEmergency Service, HospitalFemaleHumansMalePatient Acceptance of Health CareRetrospective StudiesAntidepressive Agentsdecision support techniquesdementiaearly diagnosis

Identifiers

PMID31612463
PMCPMC7094818
OpenAlexW2981048659

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.