Evidence map›Paper›PMID 31612375›Full record

ArticleGenes & genomics2020

Genome-wide identification and characterization of the AMPK genes and their distinct expression patterns in response to air exposure in the Manila clam (Ruditapes philippinarum).

Jingtian Wang, Lei Fang, Qidi Wu, Dongdong Li, Zhongming Huo, Xiwu Yan

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Article in Genes & genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jingtian WangEngineering Research Center of Shellfish Culture and Breeding in Liaoning Province, College of Fisheries and Life Science, Dalian Ocean University, No. 52, Hei Shi Jiao Street, Dalian City, 116023, China.
Lei FangEngineering Research Center of Shellfish Culture and Breeding in Liaoning Province, College of Fisheries and Life Science, Dalian Ocean University, No. 52, Hei Shi Jiao Street, Dalian City, 116023, China.
Qidi WuEngineering Research Center of Shellfish Culture and Breeding in Liaoning Province, College of Fisheries and Life Science, Dalian Ocean University, No. 52, Hei Shi Jiao Street, Dalian City, 116023, China.
Dongdong LiEngineering Research Center of Shellfish Culture and Breeding in Liaoning Province, College of Fisheries and Life Science, Dalian Ocean University, No. 52, Hei Shi Jiao Street, Dalian City, 116023, China.
Zhongming HuoEngineering Research Center of Shellfish Culture and Breeding in Liaoning Province, College of Fisheries and Life Science, Dalian Ocean University, No. 52, Hei Shi Jiao Street, Dalian City, 116023, China. hzm1983@163.com.ORCID 0000-0002-8005-4804
Xiwu YanEngineering Research Center of Shellfish Culture and Breeding in Liaoning Province, College of Fisheries and Life Science, Dalian Ocean University, No. 52, Hei Shi Jiao Street, Dalian City, 116023, China. yanxiwu@dlou.edu.cn.
Dalian Ocean University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAMP-activated protein kinases (AMPK) are heterotrimeric complexes. The main upstream phosphorylase has AMP-dependent LKB1 and Ca

methodsIn this study, we identified and characterized three AMPK genes, AMPK-α, AMPK-β, and AMPK-γ, in the Manila clam (Ruditapes philippinarum). To gain insight into the role of AMPK genes during clam energy metabolism, quantitative real-time PCR was used to investigate the expression profiles in the different stages of clam development, in healthy adult tissues, and after air exposure at two different temperatures.

resultsPhylogenetic and protein structural analyses were conducted to determine the identity and evolutionary relationships of these genes. The structural features of the genes were relatively well-conserved, relative to the AMPK genes of other vertebrates. The expression of genes was significantly induced 3-48 h after air exposure. CONCLUSINON: AMPK-α, AMPK-β and AMPK-γ are involved in clam energy metabolism. Increased expression levels of AMPK genes in the gill and intestine of Manila clam in response to air exposure implied a strong adaptability to the coastal environment.

Indexed as

AirGene Expression Regulation, DevelopmentalGenomeAmino Acid SequenceAMP-Activated Protein KinasesAnimalsBivalviaEnvironmental ExposureEvolution, MolecularGillsPhylogenyProtein ConformationAMP-Activated Protein KinasesAir exposureAMPK genesRuditapes philippinarum

Identifiers

PMID31612375
OpenAlexW2980553161

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.