ArticleJournal of fluorescence2019
A Fluorescent Probe Based on Pyrene Ring for Detecting Cys and its Application in Biology.
Article in Journal of fluorescence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Synthesis and Optical Properties of a Series of Push-Pull Dyes Based on Pyrene as the Electron Donor.Molecules (Basel, Switzerland) · 2023Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The identification of thiols has become a research hotspot due to its role in biological systems. In this work, we simply constructed a turn-on fluorescent probe named 3-(5-bromopyridin-3-yl)-1-(pyren-1-yl) prop-2-en-1-one, that a combination of pyrene ring and substituted pyridine via the connection of α, β-unsaturated ketone. Cys can destroy the space effect by Michael addition reaction, which makes the fluorescence intensity changes. Furthermore, the probe featured excellent selectivity and high sensitivity (the detection limit was 0.52 μM) by addition of Cys. Moreover, this probe suggested a potential for imaging in vivo owing to the successful imaging of the probe in HepG2 cells, zebrafish, and Arabidopsis thaliana.
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Registered trials
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