Muscle aches and pains: do I have leukemia?

Max Deschner, Chai Phua, Lalit Saini, Anargyros Xenocostas, Uday Deotare

Abstract readCase Reports

In one paragraph

Article in International journal of hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Max DeschnerDepartment of Medicine, Western University, London, ON, Canada. mdeschne@uwo.ca.ORCID http://orcid.org/0000-0002-4155-3934

Chai PhuaDepartment of Medicine, Western University, London, ON, Canada.

Lalit SainiDepartment of Medicine, Western University, London, ON, Canada.

Anargyros XenocostasDepartment of Medicine, Western University, London, ON, Canada.

Uday DeotareDepartment of Medicine, Western University, London, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe a 65-year-old man who presented with 'aches and pains' localized to the lower extremities, and was diagnosed with acute myeloid leukemia (AML). We hypothesize that this case represents an atypical presentation of AML with an immune-mediated necrotizing-like myopathy as a possible paraneoplastic manifestation of the disease, which improved after initiating chemotherapy. Our patient received a full course of 7 + 3 chemotherapy with cytarabine and daunorubicin. Proximal leg weakness and pain improved markedly following this treatment, establishing a temporal relationship between the possible paraneoplastic manifestation and treatment of underlying disease. Associations between malignancy and myopathies such as polymyositis and dermatomyositis have been well established in the literature. However, paraneoplastic IMNM is still a rare clinical phenomenon and has infrequently been associated with AML. This case may suggest myopathy and associated muscle 'aches and pains' as possible presenting symptoms of underlying AML, highlighting the heterogeneity of the clinical manifestations of this disease.

Indexed as

AgedAntineoplastic Combined Chemotherapy ProtocolsCytarabineDaunorubicinHumansLeukemia, Myeloid, AcuteLower ExtremityMaleMyalgiaCytarabineDaunorubicinAcute myeloid leukemiaIdiopathic inflammatory myopathyImmune-mediated necrotizing myopathy

Identifiers

PMID31612308

DOI10.1007/s12185-019-02746-3

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.