ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2020
Chronic performance of subxiphoid minimally invasive pericardial Model 20066 pacemaker lead insertion in an infant animal model.
Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Safety and performance of a novel subxiphoidal pacemaker system.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- New Guidelines of Pediatric Cardiac Implantable Electronic Devices: What Is Changing in Clinical Practice?Journal of cardiovascular development and disease · 2024Review
- A novel videoscope and tool kit for percutaneous pericardial access under direct visualization.Biomedical engineering online · 2023Article
- Design and Functionality of a Multilumen Thoracic Access Port for Pericardial Access Under Direct Visualization.Journal of medical devices · 2022Article
- Expanding the Reach of Pediatric Transcatheter Pacing.The Journal of innovations in cardiac rhythm management · 2021Article
- 2021 PACES expert consensus statement on the indications and management of cardiovascular implantable electronic devices in pediatric patients.Indian pacing and electrophysiology journalArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeTo describe chronic performance of subxiphoid minimally invasive pacemaker lead insertion in a piglet model.
methodsMinimally invasive pacemaker lead implantation was performed through a 10-mm incision under direct visualization using the PeriPath port. Epicardial access was obtained and the commercially available Medtronic Model 20066 pacemaker lead was inserted into the pericardial space and epicardial fixation was performed using the side-action helix. The lead was connected to a pacemaker generator in a para-rectus pocket. Animals underwent a 12-14-week observation period and lead impedances, R-wave amplitudes, and ventricular capture thresholds were tested biweekly. After the survival period, animals were euthanized and gross and histopathology were performed.
resultsSubxiphoid minimally invasive pacemaker lead placement was performed in 8 animals (median 4.9 kg) with 100% acute success. Median procedure time was 65 min (IQR 60.5-77). At implant, median lead impedance was 650 Ω (IQR 244-984), R-wave amplitude 11.1 mV (IQR 8-12.3), and ventricular capture threshold 1.5 V @ 0.4 ms (IQR 1-2.6). Over a median survival period of 13 weeks, there was a median lead impedance change of + 262 Ω (IQR 5.3-618.3), R-wave change of - 4.5 mV (IQR - 7.1-- 2.7) and capture threshold change (1.0 ms) of + 1.5 V (IQR 0-3.3). At autopsy, epicardial fixation sites showed fibrovascular proliferation and minimal chronic inflammation.
conclusionsSubxiphoid pericardial pacemaker placement is safe and effective in a piglet model. Further study and development of leads designed for pericardial placement are warranted.
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