ArticleThe Journal of clinical endocrinology and metabolism2020
The Course of Obstructive Sleep Apnea Syndrome in Patients With Acromegaly During Treatment.
Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Acromegaly complications: an update.The Journal of clinical endocrinology and metabolism · 2026Review
- Recent progress in the understanding of psychological complications of acromegaly: toward a longitudinal clinical phenotype.Pituitary · 2026Review
- Consensus on acromegaly complications: an update.Pituitary · 2026Article
- Endocrinology and the Lung: Exploring the Bidirectional Axis and Future Directions.Journal of clinical medicine · 2025Article
- Adherence, duration and healthcare costs in a real-world population of patients with acromegaly.Journal of comparative effectiveness research · 2025Article
- Oral Health and Quality of Life in Acromegaly: A Questionnaire-Based Study.Dentistry journal · 2025Article
- Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) in Patients With Acromegaly in Colombia.Cureus · 2025Article
- Biochemical Control in a Colombian Cohort of Patients With Acromegaly: A 12-Month Follow-Up Study (2017-2023).Cureus · 2024Article
- Obstructive Sleep Apnea Screening and Effects of Surgery in Acromegaly: A Prospective Study.Endocrinology and metabolism (Seoul, Korea) · 2024Observational
- The influence of radiological tumor growth pattern on sino‑nasal health in pituitary adenomas.Oncology letters · 2024Article
- Development and Validation of a Nomogram for Predicting Non-Adherence to Continuous Positive Airway Pressure Therapy in Patients with Obstructive Sleep Apnea.Nature and science of sleep · 2024Article
- Cardiovascular remodeling in active and controlled acromegaly: association with sleep-disordered breathing.Sleep & breathing = Schlaf & Atmung · 2023Article
- Quality of Life and Sleep in Patients with Pituitary Adenoma in Relation to Tumor Type and Compression of the Optic Chiasm.Journal of clinical medicine · 2021Article
- Towards an Earlier Diagnosis of Acromegaly and Gigantism.Journal of clinical medicine · 2021Review
- A Pituitary Society update to acromegaly management guidelines.Pituitary · 2021Review
- Gender Differences in the Association Between Obstructive Sleep Apnea and Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Acromegaly, inflammation and cardiovascular disease: a review.Reviews in endocrine & metabolic disorders · 2020Review
- Updates in rare and not-so-rare complications of acromegaly: focus on respiratory function and quality of life in acromegaly.F1000Research · 2020Review
- Prevalence of sleep apnea and lung function abnormalities in patients with acromegaly.Lung India : official organ of Indian Chest SocietyArticle
- Ocular and Systemic Factors Associated with Glaucoma.Journal of current glaucoma practiceReview
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObstructive sleep apnea syndrome (OSAS) is common in active acromegaly and negatively influences quality of life, morbidity, and mortality. This prospective study with 3 predetermined timepoints and a standardized treatment protocol investigates changes in sleep parameters during the first 2.5 years of acromegaly treatment.
methodsBefore initiation of acromegaly treatment (medical pretreatment followed by surgery), polysomnography (PSG) was performed in 27 consecutive patients with treatment-naive acromegaly. PSG was repeated after 1 year (N = 24) and 2.5 years (N = 23), and anthropometric and biochemical parameters were obtained.
resultsAt baseline, 74.1% of the patients was diagnosed with OSAS. The respiratory disturbance index (RDI; P = 0.001), oxygen desaturation index (ODI; P = 0.001), lowest oxygen saturation (LSaO2; P = 0.007) and the Epworth Sleepiness Scale (ESS; P < 0.001) improved significantly during treatment, with the greatest improvement in the first year. After 2.5 years of treatment, all patients had controlled acromegaly. Of the 16 patients with repeated PSG and OSAS at baseline, 11 (68.8%) were cured of OSAS. Changes in RDI, ODI, LSaO2, and ESS correlated with insulin-like growth factor 1 levels.
conclusionOSAS has a high prevalence in active acromegaly. There is a substantial decrease in prevalence and severity of OSAS following acromegaly treatment, with the largest improvement during the first year. Most patients recover from OSAS following surgical or biochemical control of the acromegaly. Therefore, a PSG is advised after diagnosis of acromegaly. When OSAS is present, it should be treated and PSG should be repeated during acromegaly treatment.
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