Evidence map›Paper›PMID 31612170›Full record

ArticleChemical communications (Cambridge, England)2019

Polymyxin derivatives as broad-spectrum antibiotic agents.

Ma Su, Minghui Wang, Yuzhu Hong, Alekhya Nimmagadda, Ning Shen, Yan Shi, Ruixuan Gao, En Zhang, Chuanhai Cao, Jianfeng Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Development of Low-Toxicity Antimicrobial Polycarbonates Bearing Lysine Residues.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ma SuDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA. jianfengcai@usf.edu.
Minghui WangDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA. jianfengcai@usf.edu.
Yuzhu HongCollege of Pharmacy, University of South Florida, Tampa, FL 33620, USA. ccao@health.usf.edu.
Alekhya NimmagaddaDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA. jianfengcai@usf.edu.
Ning ShenCollege of Pharmacy, University of South Florida, Tampa, FL 33620, USA. ccao@health.usf.edu.
Yan ShiDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA. jianfengcai@usf.edu.
Ruixuan GaoDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA. jianfengcai@usf.edu.
En ZhangDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA. jianfengcai@usf.edu and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, P. R. China.
Chuanhai CaoCollege of Pharmacy, University of South Florida, Tampa, FL 33620, USA. ccao@health.usf.edu.
Jianfeng CaiDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA. jianfengcai@usf.edu.ORCID http://orcid.org/0000-0001-9660-7875

Funding

Requesting HPLC for the project of "Alpha-AApeptides as a Novel Class of Antimicrobial Biomaterials"R01GM112652 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI CAI, JIANFENG · 2015 to 2019
$1.5M
NIGMS NIH HHS R01 GM112652
6 · The paper itself

Abstract

We designed a few polymyxin derivatives which exhibit broad-spectrum antimicrobial activity. Lead compound P1 could disrupt bacterial membranes rapidly without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in an MRSA-infected thigh burden mouse model.

Indexed as

Anti-Bacterial AgentsBiofilmsDose-Response Relationship, DrugEscherichia coliMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMolecular ConformationPolymyxinsAnti-Bacterial AgentsPolymyxins

Identifiers

PMID31612170
PMCPMC10484568

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.