Trial reportJournal of diabetes research2019
Propolis as an Adjuvant in the Healing of Human Diabetic Foot Wounds Receiving Care in the Diagnostic and Treatment Centre from the Regional Hospital of Talca.
Trial report in Journal of diabetes research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03649243 (Propolis as Adjuvant in the Healing of Human Diabetic Foot Wounds Receiving Care in Diagnostic and Treatment Center From Regional Hospital of Talca), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Propolis as Adjuvant in the Healing of Human Diabetic Foot Wounds Receiving Care in Diagnostic and Treatment Center From Regional Hospital of Talca
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Recent Update on the Anti-Inflammatory Activities of Propolis.Molecules (Basel, Switzerland) · 2022Pooled it
- Effect of Brazilian green propolis in chronic ulcer treatment: a randomized clinical trial.Revista brasileira de enfermagem · 2024Trial
- The impact of Propolis on catheter exit site infection and peritonitis in peritoneal Dialysis patients: a clinical trial.BMC nephrology · 2022Trial
- Healing the Sole: Combining Natural Plant Extracts and Conventional Drugs in Wound Delivery Systems for Diabetic Foot Ulcer Treatment.International journal of molecular sciences · 2026Review
- The impact of propolis-silver nanoparticles coated sutures versus conventional sutures on early intraoral wound healing in healthy and diabetic rats: a preliminary histological study.The Saudi dental journal · 2026Article
- Health Effects of Bee Products: A Comprehensive Review.Food science & nutrition · 2026Review
- Thermoresponsive propolis gel for gingival wound healing post-depigmentation: A prospective clinical study.Journal of Taibah University Medical Sciences · 2026Article
- Bee Products and Traditional Plant Therapies for Wound Care: a comprehensive review of scientific evidence and clinical applications.Journal of pharmacopuncture · 2025Review
- The Effect of Topical Propolis Ointment on Severity of Episiotomy Pain and Wound Healing: A Triple-Blinded Randomized Controlled Clinical Trial.Journal of caring sciences · 2025Article
- Antimicrobial Potential of Bee-Derived Products: Insights into Honey, Propolis and Bee Venom.Pathogens (Basel, Switzerland) · 2025Review
- The Efficacy of Complementary and Alternative Medicines Utilized In Cosmetic and Surgical Dermatology: A Comprehensive Review.The Journal of clinical and aesthetic dermatology · 2025Review
- Propolis Stands out as a Multifaceted Natural Product: Meta-Analysis on Its Sources, Bioactivities, Applications, and Future Perspectives.Life (Basel, Switzerland) · 2025Review
- Propolis mouthwashes efficacy in managing gingivitis and periodontitis: a systematic review of the latest findings.BDJ open · 2025Article
- Natural Ingredients to Improve Immunity.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Histological, Immunohistochemical and Antioxidant Analysis of Skin Wound Healing Influenced by the Topical Application of Brazilian Red Propolis.Antioxidants (Basel, Switzerland) · 2022Article
- Healing Potential of Propolis in Skin Wounds Evidenced by Clinical Studies.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Research Progress on Therapeutic Effect and Mechanism of Propolis on Wound Healing.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Nonwoven Releasing Propolis as a Potential New Wound Healing Method-A Review.Molecules (Basel, Switzerland) · 2021Review
- Bioactives from Bee Products and Accompanying Extracellular Vesicles as Novel Bioactive Components for Wound Healing.Molecules (Basel, Switzerland) · 2021Review
- Potential Role of Propolis in the Prevention and Treatment of Metabolic Diseases.Plants (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDiabetic foot wounds are a relevant diabetes complication and a major health problem. It has been described that propolis has health benefits due to its anti-inflammatory, antioxidant, and support in the healing process. The current study assessed the effect of propolis as an adjuvant in the healing of human diabetic foot ulcers. This was evaluated in a randomized placebo-controlled study of subjects receiving care in the Diagnostic and Treatment Centre from the Regional Hospital of Talca, Chile. RESEARCH DESIGN AND
methodsRandomized subjects received ambulatory healing treatment for diabetes foot wounds with propolis spray (3%), which was applied to cover the entire wound surface each time it was dressed from week 0 until cicatrization or 8 weeks as a maximum. Two serum samples were taken (day 0 and end of the study) for cytokine and oxidative stress analyses. Also, macro- and microscopy were analyzed in the process of wound healing.
resultsThe study comprised 31 subjects with type 2 diabetes in treatment for diabetic foot wounds in the Diagnostic and Treatment Centre from the Regional Hospital of Talca. Propolis promotes a reduction of the wound's area by an average of 4 cm
conclusionsThe topical use of propolis turned out to be an interesting therapeutic strategy as an adjuvant in the care of diabetes foot wounds due to its ability to improve and promote healing based on its anti-inflammatory and antioxidant profile. This trial is registered with NCT03649243.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.