Evidence map›Paper›PMID 31611956›Full record

ArticleOncology letters2019

Plasma exosome-encapsulated microRNA-21 and microRNA-92a are promising biomarkers for the prediction of peritoneal recurrence in patients with gastric cancer.

Naruyoshi Soeda, Hisae Iinuma, Yusuke Suzuki, Daisuke Tsukahara, Hironori Midorikawa, Yuichi Igarashi, Yoshimasa Kumata, Masahiro Horikawa, Takashi Kiyokawa, Takeo Fukagawa and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  7. Functions and Clinical Applications of Exosomes in Gastric Cancer.International journal of biological sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Naruyoshi SoedaDepartment of Surgery, Teikyo University School of Medicine, Itabashi, Tokyo 173-0003, Japan.
Hisae IinumaDepartment of Surgery, Teikyo University School of Medicine, Itabashi, Tokyo 173-0003, Japan.
Yusuke SuzukiDepartment of Surgery, Teikyo University School of Medicine, Itabashi, Tokyo 173-0003, Japan.
Daisuke TsukaharaDepartment of Surgery, Teikyo University School of Medicine, Itabashi, Tokyo 173-0003, Japan.
Hironori MidorikawaDepartment of Surgery, Teikyo University School of Medicine, Itabashi, Tokyo 173-0003, Japan.
Yuichi IgarashiDepartment of Surgery, Teikyo University School of Medicine, Itabashi, Tokyo 173-0003, Japan.
Yoshimasa KumataDepartment of Surgery, Teikyo University School of Medicine, Itabashi, Tokyo 173-0003, Japan.
Masahiro HorikawaDepartment of Surgery, Teikyo University School of Medicine, Itabashi, Tokyo 173-0003, Japan.
Takashi KiyokawaDepartment of Surgery, Teikyo University School of Medicine, Itabashi, Tokyo 173-0003, Japan.
Takeo FukagawaDepartment of Surgery, Teikyo University School of Medicine, Itabashi, Tokyo 173-0003, Japan.
Ryoji FukushimaDepartment of Surgery, Teikyo University School of Medicine, Itabashi, Tokyo 173-0003, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with gastric cancer (GC), peritoneal recurrence is a common risk and associated with poor prognosis. A novel biomarker for the prediction of high-risk peritoneal recurrence in patients with GC is desirable. The present study investigated the effectiveness of exosome-encapsulated microRNAs (ex-miRNAs) as minimally invasive biomarkers in patients with GC that received curative surgery. Recurrence-specific ex-miRNAs were selected following comparison of miRNA microarray data from patients with TNM stage II GC with peritoneal recurrence (n=3) and without peritoneal recurrence following curative surgery (n=3), and three healthy volunteers. In this analysis, exosome-encapsulated miRNA-21 (ex-miR-21) and exosomal miR-92a (ex-miR-92a) exhibited the greatest alterations in expression patterns. Using plasma exosome samples collected from another 129 patients with stage II and III GC, the present study investigated the potential value of ex-miR-21 and ex-miR-92a as biomarkers. Ex-miRNA levels were measured using TaqMan miRNA assays. Ex-miR-21 levels were significantly higher and ex-miR-92a levels were significantly lower in samples from patients with GC compared with healthy controls. The overall survival (OS) and peritoneal recurrence-free survival (PRFS) were poorer in stage II and III patients with high ex-miR-21 levels than in patients with low miR-21 levels. OS and PRFS of stage II and III patients with low ex-miR92a levels were significantly worse than those with high ex-miR92a levels. Cox multivariate analyses indicated that ex-miR-21 and ex-miR-92a were independent prognostic factors for OS and PRFS in stage II and III GC. A negative correlation was detected between expression levels of miR-21 and programmed cell death protein 4 mRNA, and miR-92a and prostaglandin E receptor 4 mRNA. Therefore, ex-miR-21 and ex-miR-92a may function as effective and minimally invasive biomarkers for the prediction of peritoneal recurrence and the prognosis of patients with stage II/III GC.

Indexed as

exosomegastric cancerliquid biomarkermiRNA-21miRNA-92aperitoneal recurrenceprognosis

Identifiers

PMID31611956
PMCPMC6781766

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.