Evidence map›Paper›PMID 31611867›Full record

ArticleFrontiers in microbiology2019

Fecal Microbiome Characteristics and the Resistome Associated With Acquisition of Multidrug-Resistant Organisms Among Elderly Subjects.

Rafael Araos, Thomas Battaglia, Juan A Ugalde, Marcelo Rojas-Herrera, Martin J Blaser, Erika M C D'Agata

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Rafael AraosInstituto de Ciencias e Innovación en Medicina, and Millennium Initiative for Collaborative Research on Bacterial Resistance (MICROB-R), Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.
Thomas BattagliaCentre for Integrative Bioinformatics (IBIVU), VU University of Amsterdam, Amsterdam, Netherlands.
Juan A UgaldeInstituto de Ciencias e Innovación en Medicina, and Millennium Initiative for Collaborative Research on Bacterial Resistance (MICROB-R), Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.
Marcelo Rojas-HerreraInstituto de Ciencias e Innovación en Medicina, and Millennium Initiative for Collaborative Research on Bacterial Resistance (MICROB-R), Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.
Martin J BlaserCenter for Advanced Biotechnology and Medicine, Rutgers University, New Brunswick, NJ, United States.
Erika M C D'AgataRhode Island Hospital, Brown University, Providence, RI, United States.
Clínica Alemana · CLBrown University · USRutgers, The State University of New Jersey · USUniversidad del Desarrollo · CLUniversity of Amsterdam · NL

Funding

Determinants, Decision-Making and Outcomes of Antibiotic Use in Advanced DementiaR01AG032982 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI D'AGATA, ERIKA M, MITCHELL, SUSAN L · 2009 to 2013
$2.9M
Midcareer Investigator Award in Patient-Oriented ResearchK24AI119158 · NIAID · RHODE ISLAND HOSPITAL · PI D'AGATA, ERIKA M · 2016 to 2020
$885k
NIAID NIH HHS K24 AI119158NIA NIH HHS R01 AG032982
6 · The paper itself

Abstract

Infections caused by multidrug-resistant organisms (MDRO) lead to considerable morbidity and mortality. The elderly population residing in nursing homes are a major reservoir of MDRO. Our objective was to characterize the fecal microbiome of 82 elderly subjects from 23 nursing homes and compare their resistome to that of healthy young persons. Comparisons of microbiome composition and the resistome between subjects who acquired MDRO or not were analyzed to characterize specific microbiome disruption indices (MDI) associated with MDRO acquisition. An approach based on both 16S rRNA amplicon and whole metagenome shotgun (WMS) sequencing data was used. The microbiome of the study cohort was substantially perturbed, with

Indexed as

16S rRNA amplicon sequencingantibiotic resistancegeriatricsmultidrug-resistant organismswhole metagenome shotgun sequencing

Identifiers

PMID31611867
PMCPMC6777474
OpenAlexW2975055699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.