ReviewFrontiers in molecular neuroscience2019
Can NMDA Spikes Dictate Computations of Local Networks and Behavior?
Review in Frontiers in molecular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- Calmodulin controls spatial and temporal specificity of calcium-induced calcium release.PLoS computational biology · 2026Article
- Robust input disentanglement through dendritic calcium-mediated action potentials.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Context-dependent NMDA receptor dysfunction predicts seizure treatment in mice with human GluN1 variant.iScience · 2026Article
- Electric field effects on neuronal input-output relationship by regulating NMDA spikes.Cognitive neurodynamics · 2024Article
- Review
- Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit.Cell reports · 2023Article
- Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders.Frontiers in neural circuits · 2022Review
- Periodicity Pitch Perception Part III: Sensibility and Pachinko Volatility.Frontiers in neuroscience · 2022Article
- Dynorphin/Kappa-Opioid Receptor System Modulation of Cortical Circuitry.Handbook of experimental pharmacology · 2022Review
- Dying-back of ascending noradrenergic projections in Parkinson's disease.Brain : a journal of neurology · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intelligence is the ability to learn appropriate responses to stimuli and the capacity to master new skills. Synaptic integration at the dendritic level is thought to be essential for this ability through linear and non-linear processing, by allowing neurons to be tuned to relevant information and to maximize adaptive behavior. Showing that dendrites are able to generate local computations that influence how animals perceive the world, form a new memory or learn a new skill was a break-through in neuroscience, since in the past they were seen as passive elements of the neurons, just funneling information to the soma. Here, we provide an overview of the role of dendritic integration in improving the neuronal network and behavioral performance. We focus on how NMDA spikes are generated and their role in neuronal computation for optimal behavioral output based on recent
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Registered trials
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