ArticleNature chemical biology2019
Long-range temporal coordination of gene expression in synthetic microbial consortia.
Article in Nature chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Signed, sealed, delivered: a generalizable model for living biotherapeutic dosing and metabolism.NPJ systems biology and applications · 2026Article
- BioFuse: A programmable timer switch of gene expression.Science advances · 2025Article
- Engineering coupled consortia-based biosensors for diagnostic.Nature communications · 2025Article
- Framework nucleic acid strategy enables closer microbial contact for programming short-range interaction.Science advances · 2024Article
- Article
- Synthetic Homoserine Lactone Sensors for Gram-PositiveACS synthetic biology · 2024Article
- Engineering microbial division of labor for plastic upcycling.Nature communications · 2023Article
- Spatial biology of Ising-like synthetic genetic networks.BMC biology · 2023Article
- Signaling in microbial communities with open boundaries.Biophysical journal · 2023Article
- Signaling in microbial communities with open boundaries.bioRxiv : the preprint server for biology · 2023Article
- The space between us: Modeling spatial heterogeneity in synthetic microbial consortia dynamics.Biophysical reports · 2022Article
- Probing patterning in microbial consortia with a cellular automaton for spatial organisation.Scientific reports · 2022Article
- Calibrating spatiotemporal models of microbial communities to microscopy data: A review.PLoS computational biology · 2022Review
- Rhythmic transcription of Bmal1 stabilizes the circadian timekeeping system in mammals.Nature communications · 2022Article
- Engineering microbial consortia with rationally designed cellular interactions.Current opinion in biotechnology · 2022Review
- Combined multiple transcriptional repression mechanisms generate ultrasensitivity and oscillations.Interface focus · 2022Article
- Engineered microbial consortia: strategies and applications.Microbial cell factories · 2021Review
- Review
- Emergent spatiotemporal population dynamics with cell-length control of synthetic microbial consortia.PLoS computational biology · 2021Article
- Synchronization of gene expression across eukaryotic communities through chemical rhythms.Nature communications · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Synthetic microbial consortia have an advantage over isogenic synthetic microbes because they can apportion biochemical and regulatory tasks among the strains. However, it is difficult to coordinate gene expression in spatially extended consortia because the range of signaling molecules is limited by diffusion. Here, we show that spatio-temporal coordination of gene expression can be achieved even when the spatial extent of the consortium is much greater than the diffusion distance of the signaling molecules. To do this, we examined the dynamics of a two-strain synthetic microbial consortium that generates coherent oscillations in small colonies. In large colonies, we find that temporally coordinated oscillations across the population depend on the presence of an intrinsic positive feedback loop that amplifies and propagates intercellular signals. These results demonstrate that synthetic multicellular systems can be engineered to exhibit coordinated gene expression using only transient, short-range coupling among constituent cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.