ArticleHeredity2019
Genetic dissection of complex behaviour traits in German Shepherd dogs.
Article in Heredity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Genome-wide association studies for canine hip dysplasia in single and multiple populations - implications and potential novel risk loci.BMC genomics · 2021Pooled it
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- GWAS for behavioral traits in golden retrievers identifies genes implicated in human temperament, mental health, and cognition.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genetic testing predicts appearance but not behavior in dogs.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Take a Look Towards the Stress Response of Working Dogs: Cortisol and Lactate Trend Mismatches During Training.Animals : an open access journal from MDPI · 2025Article
- Genome-wide study suggests inheritance of personality traits in Toy Poodles and Miniature Dachshunds.Animal genetics · 2025Article
- Exploring breed differences in discrimination, reversal learning, and resistance to extinction in the domestic dog (Canis familiaris).Scientific reports · 2024Article
- Transposons in the Williams-Beuren Syndrome Critical Region are Associated with Social Behavior in Assistance Dogs.Behavior genetics · 2024Article
- The Shepherd and the Hunter: A Genomic Comparison of Italian Dog Breeds.Animals : an open access journal from MDPI · 2023Article
- Article
- Genetic dissection of behavioral traits related to successful training of drug detection dogs.Scientific reports · 2023Article
- Best practices for analyzing imputed genotypes from low-pass sequencing in dogs.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Article
- CyberGenomics: Application of Behavioral Genetics in Cybersecurity.Behavioral sciences (Basel, Switzerland) · 2021Review
- Man's best friend in life and death: scientific perspectives and challenges of dog brain banking.GeroScience · 2021Review
- A novel canine reference genome resolves genomic architecture and uncovers transcript complexity.Communications biology · 2021Article
- Unravelling selection signatures in a single dog breed suggests recent selection for morphological and behavioral traits.Advanced genetics (Hoboken, N.J.) · 2020Article
- Methods to Improve Joint Genetic Evaluation of Canine Hip Dysplasia Across BVA/KC and FCI Screening Schemes.Frontiers in veterinary science · 2020Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A favourable genetic structure and diversity of behavioural features highlights the potential of dogs for studying the genetic architecture of behaviour traits. However, behaviours are complex traits, which have been shown to be influenced by numerous genetic and non-genetic factors, complicating their analysis. In this study, the genetic contribution to behaviour variation in German Shepherd dogs (GSDs) was analysed using genomic approaches. GSDs were phenotyped for behaviour traits using the established Canine Behavioural Assessment and Research Questionnaire (C-BARQ). Genome-wide association study (GWAS) and regional heritability mapping (RHM) approaches were employed to identify associations between behaviour traits and genetic variants, while accounting for relevant non-genetic factors. By combining these complementary methods we endeavoured to increase the power to detect loci with small effects. Several behavioural traits exhibited moderate heritabilities, with the highest identified for Human-directed playfulness, a trait characterised by positive interactions with humans. We identified several genomic regions associated with one or more of the analysed behaviour traits. Some candidate genes located in these regions were previously linked to behavioural disorders in humans, suggesting a new context for their influence on behaviour characteristics. Overall, the results support dogs as a valuable resource to dissect the genetic architecture of behaviour traits and also highlight the value of focusing on a single breed in order to control for background genetic effects and thus avoid limitations of between-breed analyses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.