ArticleNature communications2019
Evaluation of integrin αvβ
3 registry-linked trialsOpen access · goldAbstract read
In one paragraph
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 68 papers.
0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
8.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Detection of Integrin avb6 in Idiopathic Pulmonary Fibrosis, Primary Sclerosing Cholangitis, and Coronavirus Disease 2019 With [18F]FP-R01-MG-F2 With PET/CT
A Single-arm, Open-label, Single-center Clinical Study to the Evaluation of Integrin αvβ6-targeted Positron Emission Tomography (PET) for Malignant Tumors
NCT07420036 early_phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation
An Open-label, Single-arm, Single-center Study to Evaluate the Diagnostic Efficacy of a Novel PET Probe, 68Ga-SFB6-ZN01, in Patients With Malignant Tumors
Who cites it
68 citing papers in PubMed, 110 citations in OpenAlex.
- Bexotegrast Shows Dose-Dependent Integrin αAnnals of the American Thoracic Society · 2025Trial
- A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor.Respiratory research · 2020Trial
- Conformational Preference Classification of Integrin-Binding Ligands Using Free Energy Perturbation.JACS Au · 2026Article
- Article
- Molecular PET imaging of integrin αvβ6 reveals biliary and fibrotic changes in preclinical MASH.Biomarker research · 2026Article
- Linker Optimization in Lu-177 Labeled αvβ6-Integrin Binding Peptide Trimers for Targeted Radionuclide Therapy of Cancer.Molecular pharmaceutics · 2026Article
- Comparison of theMolecular therapy. Oncology · 2026Article
- Development of LRRC15-binding disulfide-constrained peptides for PET imaging of cancer-associated fibroblasts.Nature communications · 2026Article
- Immunohistochemical Expression of Integrin αBiomolecules · 2026Article
- Synthesis and preclinical development of a novelEJNMMI radiopharmacy and chemistry · 2026Article
- The importance of mechanical forces in chronic respiratory diseases.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- PET/CT imaging of esophageal cancer targeting tumor cell specific αvβ6-integrin expression.European journal of nuclear medicine and molecular imaging · 2025Article
- Article
- Pulmonary Fibrosis-Focusing on the Future: Aspen Lung Conference 2024 Summary.American journal of respiratory cell and molecular biology · 2025Article
- Fibrotic Disease: from Signaling Pathways and Biomarkers to Molecular Imaging.Molecular imaging and biology · 2025Review
- [European journal of nuclear medicine and molecular imaging · 2025Article
- Cancer-Associated Fibroblasts: Heterogeneity, Cancer Pathogenesis, and Therapeutic Targets.MedComm · 2025Review
- Mechanisms on How Matricellular Microenvironments Sustain Idiopathic Pulmonary Fibrosis.International journal of molecular sciences · 2025Review
- Molecular Imaging of Pulmonary Fibrosis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Review
- Blockade of αvβ6 and αvβ8 integrins with a chromogranin A-derived peptide inhibits TGFβ activation in tumors and suppresses tumor growth.Journal of experimental & clinical cancer research : CR · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
42 authors at 6 institutions in 3 countries.
Richard H KimuraDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Ling WangDepartment of Nuclear Medicine, Peking Union Medical College, Beijing, 100730, China.
Bin ShenDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Li HuoDepartment of Nuclear Medicine, Peking Union Medical College, Beijing, 100730, China.
Willemieke TummersDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Fabian V FilippCancer Systems Biology, Institute of Computational Biology, Helmholtz Zentrum München, Ingolstädter Landstraße 1, D-85764, München, Germany.ORCID http://orcid.org/0000-0001-9889-5727
Haiwei Henry GuoDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0001-5511-1750
Thomas HaywoodDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Lotfi Abou-ElkacemDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Lucia BarattoDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Frezghi HabteDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Rammohan DevulapallyDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Timothy H WitneyDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Yan ChengDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Suhas TikoleCancer Systems Biology, Institute of Computational Biology, Helmholtz Zentrum München, Ingolstädter Landstraße 1, D-85764, München, Germany.
Subhendu ChakrabortiDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-4117-9719
Jay NixAdvanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0002-4041-4975
Christopher A BonaguraArt Robbins Instruments, Sunnyvale, CA, 94089, USA.
Negin HatamiDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Joshua J MooneyDepartment of Medicine, Stanford University, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-4687-194X
Tushar DesaiDepartment of Internal Medicine, Stanford University, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-8794-5319
Scott TurnerPliant Therapeutics, Redwood City, CA, 94063, USA.
Richard S GasterDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Andrea OtteDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-5800-8000
Brendan C VisserDepartment of Surgery, Stanford University, Stanford, CA, 94305, USA.
George A PoultsidesDepartment of Surgery, Stanford University, Stanford, CA, 94305, USA.
Jeffrey NortonDepartment of Surgery, Stanford University, Stanford, CA, 94305, USA.
Walter ParkDepartment of Medicine, Stanford University, Stanford, CA, 94305, USA.
Mark StolowitzDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Kenneth LauDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Eric YangDepartment of Pathology, Stanford University, Stanford, CA, 95305, USA.
Arutselvan NatarajanDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-9958-2623
Ohad IlovichDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Shyam SrinivasDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Ananth SrinivasanDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Ramasamy PaulmuruganDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Juergen WillmannDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Frederick T ChinDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Zhen ChengDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0001-8177-9463
Andrei IagaruDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Fang LiDepartment of Nuclear Medicine, Peking Union Medical College, Beijing, 100730, China.
Sanjiv S GambhirDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA. sgambhir@stanford.edu.ORCID http://orcid.org/0000-0001-7453-3158
Stanford University · USChinese Academy of Medical Sciences & Peking Union Medical College · CNHelmholtz Zentrum München · DELawrence Berkeley National Laboratory · USPliant (United States) · USStanford Medicine · US
Funding
Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Vittorio Sebastiano · 2007 to 2026
$71.4MMolecular Imaging Methods for the Detection of Pancreatic Ductal AdenocarcinomaU01CA210020 · NCI · STANFORD UNIVERSITY · PI IAGARU, ANDREI, PARK, WALTER GWANG-UP · 2017 to 2021
$4.1MTumor pyruvate kinase as key regulator of cancer metabolismR00CA154887 · NCI · UNIVERSITY OF CALIFORNIA, MERCED · PI FILIPP, FABIAN VOLKER · 2012 to 2014
$725kTumor pyruvate kinase as key regulator of cancer metabolismK99CA154887 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI FILIPP, FABIAN VOLKER · 2011 to 2012
$177kNCI NIH HHS K99 CA154887NCI NIH HHS P30 CA124435NCI NIH HHS R00 CA154887NCI NIH HHS U01 CA210020
Abstract
Advances in precision molecular imaging promise to transform our ability to detect, diagnose and treat disease. Here, we describe the engineering and validation of a new cystine knot peptide (knottin) that selectively recognizes human integrin αvβ
Indexed as
Antigens, NeoplasmCrystallography, X-RayHealthy VolunteersHumansIdiopathic Pulmonary FibrosisIntegrinsMagnetic Resonance ImagingNeoplasmsPositron-Emission TomographyAntigens, Neoplasmintegrin alphavbeta6Integrins
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.