Evidence map›Paper›PMID 31611558›Full record

ArticleCell death & disease2019

Inhibition of Tet1- and Tet2-mediated DNA demethylation promotes immunomodulation of periodontal ligament stem cells.

Tingting Yu, Dawei Liu, Ting Zhang, Yanheng Zhou, Songtao Shi, Ruili Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 40 citations in OpenAlex.

  1. [Progress in regulating stem cell functions for repair and regeneration of craniomaxillofacial tissues].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026
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  10. FasL is a catabolic factor in alveolar bone homeostasis.Journal of clinical periodontology · 2023
    Article
  11. Review
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  13. Mechanically Robust Hydrogels Facilitating Bone Regeneration through Epigenetic Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Tingting YuDepartment of Orthodontics, Peking University School and Hospital of Stomatology, #22 Zhongguancun South Avenue, 100081, Beijing, China.ORCID http://orcid.org/0000-0001-8642-133X
Dawei LiuDepartment of Orthodontics, Peking University School and Hospital of Stomatology, #22 Zhongguancun South Avenue, 100081, Beijing, China.
Ting ZhangDepartment of Orthodontics, Peking University School and Hospital of Stomatology, #22 Zhongguancun South Avenue, 100081, Beijing, China.
Yanheng ZhouDepartment of Orthodontics, Peking University School and Hospital of Stomatology, #22 Zhongguancun South Avenue, 100081, Beijing, China.
Songtao ShiDepartment of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ruili YangDepartment of Orthodontics, Peking University School and Hospital of Stomatology, #22 Zhongguancun South Avenue, 100081, Beijing, China. ruiliyangabc@163.com.
Peking University · CNStomatology Hospital · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontal ligament stem cells (PDLSCs) possess great potential for clinical treatment of immune diseases due to their extensive immunomodulatory properties. However, the underlying mechanisms that govern the immunomodulatory properties of mesenchymal stem cells (MSCs) are still not fully elucidated. Here, we show that member of the Ten-eleven translocation (Tet) family, a group of DNA demethylases, are capable of regulating PDLSC immunomodulatory functions. Tet1 and Tet2 deficiency enhance PDLSC-induced T cell apoptosis and ameliorate the disease phenotype in colitis mice. Mechanistically, we found that downregulation of Tet1 and Tet2 leads to hypermethylation of DKK-1 promoter, leading to the activation of WNT signaling pathway and therefore promoting Fas ligand (FasL) expression, which results in elevated immunomodulatory capacity of PDLSCs. These results reveal a previously unrecognized role of Tet1 and Tet2 in regulating immunomodulation of PDLSCs. This Tet/DKK-1/FasL cascade may serve as a promising target for enhancing PDLSC-based immune therapy.

Indexed as

AnimalsCell DifferentiationCell ProliferationColitisDioxygenasesDisease Models, AnimalDNA-Binding ProteinsDNA DemethylationDNA MethylationFas Ligand ProteinGene Expression Regulation, DevelopmentalHumansIntercellular Signaling Peptides and ProteinsMesenchymal Stem CellsMicePeriodontal LigamentDioxygenasesDkk1 protein, mouseDNA-Binding ProteinsFas Ligand ProteinIntercellular Signaling Peptides and ProteinsProto-Oncogene ProteinsTET1 protein, mouseTet2 protein, mouse

Identifiers

PMID31611558
PMCPMC6791886
OpenAlexW2979801866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.