ArticleNature communications2019
IRF2 is a master regulator of human keratinocyte stem cell fate.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Article
- Pyroptosis-Related Gene Signatures Enable Robustly Diagnosis, Prognosis and Immune Responses Prediction in Uterine Corpus Endometrial Carcinoma.Journal of Cancer · 2025Article
- Benchmarking tools for transcription factor prioritization.Computational and structural biotechnology journal · 2024Article
- PMF-GRN: a variational inference approach to single-cell gene regulatory network inference using probabilistic matrix factorization.Genome biology · 2024Article
- Molecular characterization of chronic cutaneous wounds reveals subregion- and wound type-specific differential gene expression.International wound journal · 2024Article
- Immortalization of patient-derived lip cells for establishing 3D lip models.Frontiers in cell and developmental biology · 2024Article
- An MRTF-A-ZEB1-IRF9 axis contributes to fibroblast-myofibroblast transition and renal fibrosis.Experimental & molecular medicine · 2023Article
- Research and Therapeutic Approaches in Stem Cell Genome Editing by CRISPR Toolkit.Molecules (Basel, Switzerland) · 2023Review
- IRF2 is required for development and functional maturation of human NK cells.Frontiers in immunology · 2022Article
- Safe and stable generation of induced pluripotent stem cells using doggybone DNA vectors.Molecular therapy. Methods & clinical development · 2021Article
- Whole genome sequencing identifies novel genetic mutations in patients with eczema herpeticum.Allergy · 2021Article
- IRF2-mediated upregulation of lncRNA HHAS1 facilitates the osteogenic differentiation of bone marrow-derived mesenchymal stem cells by acting as a competing endogenous RNA.Clinical and translational medicine · 2021Article
- Interaction of the NRF2 and p63 transcription factors promotes keratinocyte proliferation in the epidermis.Nucleic acids research · 2021Article
- ChIP-BIT2: a software tool to detect weak binding events using a Bayesian integration approach.BMC bioinformatics · 2021Article
- BET bromodomain inhibitors regulate keratinocyte plasticity.Nature chemical biology · 2021Article
- Core transcriptional regulatory circuitries in cancer.Oncogene · 2020Review
- ZBED2 is an antagonist of interferon regulatory factor 1 and modifies cell identity in pancreatic cancer.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Delivery of α1-Antitrypsin Therapy Through Transepidermal Route: Worthwhile to Explore.Frontiers in pharmacology · 2020Article
Corrections and comments
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Authors and funding
27 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resident adult epithelial stem cells maintain tissue homeostasis by balancing self-renewal and differentiation. The stem cell potential of human epidermal keratinocytes is retained in vitro but lost over time suggesting extrinsic and intrinsic regulation. Transcription factor-controlled regulatory circuitries govern cell identity, are sufficient to induce pluripotency and transdifferentiate cells. We investigate whether transcriptional circuitry also governs phenotypic changes within a given cell type by comparing human primary keratinocytes with intrinsically high versus low stem cell potential. Using integrated chromatin and transcriptional profiling, we implicate IRF2 as antagonistic to stemness and show that it binds and regulates active cis-regulatory elements at interferon response and antigen presentation genes. CRISPR-KD of IRF2 in keratinocytes with low stem cell potential increases self-renewal, migration and epidermis formation. These data demonstrate that transcription factor regulatory circuitries, in addition to maintaining cell identity, control plasticity within cell types and offer potential for therapeutic modulation of cell function.
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