Evidence map›Paper›PMID 31611550›Full record

ArticleBlood cancer journal2019

SIRPα expression delineates subsets of intratumoral monocyte/macrophages with different functional and prognostic impact in follicular lymphoma.

Ya-Ping Chen, Hyo Jin Kim, Hongyan Wu, Tammy Price-Troska, Jose C Villasboas, Shahrzad Jalali, Andrew L Feldman, Anne J Novak, Zhi-Zhang Yang, Stephen M Ansell

Open access · goldAbstract read
In one paragraph

Article in Blood cancer journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. A Phase I Trial of Evorpacept, Lenalidomide, and Rituximab for Patients with B-Cell Non-Hodgkin Lymphoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  8. Article
  9. Article
  10. Deciphering the role of CD47 in cancer immunotherapy.Journal of advanced research · 2024
    Review
  11. Review
  12. Review
  13. Follicular lymphoma microenvironment: insights provided by single-cell analysis.Journal of clinical and experimental hematopathology : JCEH · 2023
    Review
  14. Review
  15. Article
  16. Reversal of Lactate and PD-1-mediated Macrophage Immunosuppression Controls Growth of PTEN/p53-deficient Prostate Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
  17. Advances in the multi-omics landscape of follicular lymphoma.International journal of biological sciences · 2023
    Review
  18. Article
  19. CD47/SIRPα axis: bridging innate and adaptive immunity.Journal for immunotherapy of cancer · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Ya-Ping ChenDivision of Hematology and Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Hyo Jin KimDivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Hongyan WuDepartment of Immunology, Medical College, China Three Gorges University, Yichang, Hubei, China.
Tammy Price-TroskaDivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Jose C VillasboasDivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Shahrzad JalaliDivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Andrew L FeldmanDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-5009-4808
Anne J NovakDivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Zhi-Zhang YangDivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA. yang.zhizhang@mayo.edu.
Stephen M AnsellDivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA. ansell.stephen@mayo.edu.
Mayo Clinic in Arizona · USChina Three Gorges University · CNMayo Clinic · USNational Cheng Kung University Hospital · TW

Funding

The Role of Monocytes in non-Hodgkin LymphomaP50CA097274 · NCI · UNIVERSITY OF IOWA · PI HOUTMAN, JON C.D. · 2002 to 2021
$45.7M
6 · The paper itself

Abstract

Signal regulatory protein-α (SIRPα) is a key member of the "do-not-eat-me" signaling pathway, but its biological role and clinical relevance in B-cell NHL is relatively unknown. Using biopsy specimens from follicular lymphoma (FL), we identified three subsets (CD14

Indexed as

Antigens, CDAntigens, DifferentiationAntigens, Differentiation, MyelomonocyticBiomarkers, TumorCD68 MoleculeHumansLipopolysaccharide ReceptorsLymphoma, FollicularMacrophagesMiddle AgedMonocytesPrognosisReceptors, ImmunologicSurvival RateAntigens, CDAntigens, DifferentiationAntigens, Differentiation, MyelomonocyticBiomarkers, TumorCD14 protein, humanCD68 antigen, humanCD68 MoleculeLipopolysaccharide ReceptorsReceptors, ImmunologicSIRPA protein, human

Identifiers

PMID31611550
PMCPMC6791879
OpenAlexW2979973225

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.