ArticleThe Journal of veterinary medical science2019
First isolation of voriconazole-resistant Candida albicans, C. tropicalis, and Aspergillus niger from the blowholes of bottlenose dolphins (Tursiops truncatus).
Article in The Journal of veterinary medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Azole resistance inFrontiers in veterinary science · 2025Pooled it
- Culture-based characterization of the respiratory mycobiota and antifungal resistance in bottlenose dolphins under human care.One health (Amsterdam, Netherlands) · 2026Article
- Candida Infections in Marine Mammals: Epidemiology, Antifungal Resistance, and One Health Implications.Animals : an open access journal from MDPI · 2026Review
- Neutrophil differentials in bronchoalveolar lavage fluid in bottlenose dolphins (Tursiops truncatus) and beluga whales (Delphinapterus leucas) during treatment of respiratory infection: a preliminary study.Veterinary research communications · 2026Article
- Antifungal Resistance and Synergistic Therapy in Candida Spp. Isolated From Bottlenose Dolphins Under Human Care: Implications for One Health Management.Veterinary medicine and science · 2025Article
- Bronchoalveolar lavage fluid is superior to blow samples for the identification of fungi in the lower respiratory tract of beluga whales (Delphinapterus leucas).The Journal of veterinary medical science · 2025Article
- An update on captive cetacean welfare.PeerJ · 2025Review
- Review
- Potential Fungal Zoonotic Pathogens in Cetaceans: An Emerging Concern.Microorganisms · 2024Review
- Isolation of antifungal-resistant Candida from the blowholes of captive dolphins.The Journal of veterinary medical science · 2022Article
- The emerging threat antifungal-resistantFrontiers in fungal biology · 2022Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary mycosis is a fungal disease that commonly affects bottlenose dolphins (Tursiops truncatus) and is generally treated by the oral administration of azoles, such as itraconazole (ITZ) and voriconazole (VRZ). However, antifungal susceptibility testing of clinical isolates has not been well performed as a routine clinical examination in aquaria. In this study, we collected fungal species from the blowholes of 14 bottlenose dolphins, of which 12 were treated with ITZ or VRZ. All dolphins were housed in the Port of Nagoya Public Aquarium. The fungal species Candida albicans, C. tropicalis, C. glabrata, Aspergillus fumigatus, and A. niger were isolated. E-tests were performed to determine the minimum inhibitory concentrations (MICs) of ITZ and VRZ on these isolates. VRZ-resistant C. tropicalis (MIC: >32 µg/ml) and A. niger (MIC: >32 µg/ml) were isolated from three dolphins treated with ITZ or VRZ. Additionally, azole-resistant isolates of C. albicans and C. glabrata were collected from two dolphins that had never received azole therapy. To the best of our knowledge, our study is the first to report the isolation of VRZ-resistant C. albicans, C. tropicalis, and A. niger from the blowholes of bottlenose dolphins. Thus, antifungal susceptibility testing is a crucial strategy for selecting antifungal agents to treat respiratory fungal infections in bottlenose dolphins in aquaria.
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