Evidence map›Paper›PMID 31611415›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Trait-like variants in human functional brain networks.

Benjamin A Seitzman, Caterina Gratton, Timothy O Laumann, Evan M Gordon, Babatunde Adeyemo, Ally Dworetsky, Brian T Kraus, Adrian W Gilmore, Jeffrey J Berg, Mario Ortega and 8 more

Registry-linked trialAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07024875 (Precision Neuroimaging of Parkinson's Disease), which is not on this map. Cited by 146 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07024875 recruitingnot on this mapstarted 2025, after this paper: background citation

Precision Neuroimaging of Parkinson's Disease

Typeobservational_patient_registrySponsorWashington University School of MedicineRan2025 to 2031Enrolled120ConditionsParkinsons Disease (PD)
3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Individualized Network Topography in Pre-adolescent Children and Adults Using Naturalistic Precision fMRI.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Functional brain organization is stable within individuals across years.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Individualized Mapping of Functional Brain Networks in Older Adulthood.bioRxiv : the preprint server for biology · 2026
    Article
  16. Article
  17. Review
  18. Article
  19. Considerations for conducting developmental neuroimaging research on mental health topics.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  20. Article

86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Benjamin A SeitzmanDepartment of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110; seitzman@wustl.edu caterina.gratton@northwestern.edu.
Caterina GrattonDepartment of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110; seitzman@wustl.edu caterina.gratton@northwestern.edu.
Timothy O LaumannDepartment of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Evan M GordonVeterans Integrated Service Network 17 Center of Excellence for Research on Returning War Veterans, Waco, TX 76711.
Babatunde AdeyemoDepartment of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Ally DworetskyDepartment of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Brian T KrausDepartment of Psychology, Northwestern University, Evanston, IL 60208.
Adrian W GilmoreDepartment of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO 63130.
Jeffrey J BergDepartment of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO 63130.
Mario OrtegaDepartment of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Annie NguyenDepartment of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Deanna J GreeneDepartment of Psychiatry, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Kathleen B McDermottDepartment of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO 63130.
Steven M NelsonVeterans Integrated Service Network 17 Center of Excellence for Research on Returning War Veterans, Waco, TX 76711.
Christina N Lessov-SchlaggarDepartment of Psychiatry, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Bradley L SchlaggarDepartment of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Nico U F DosenbachDepartment of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Steven E PetersenDepartment of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.

Funding

TRAINING PROGRAM IN THE NEUROSCIENCE OF HUMAN COGNITIONT32NS047987 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Rodrigo M Braga, Christina Maria Zelano · 2006 to 2026
$5.6M
Sources and Functional Consequences of Individual Differences in Human Functional Brain Networks Related to Controlled BehaviorR01MH118370 · NIMH · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI GRATTON, CATERINA · 2019 to 2023
$3.4M
Washington University Psychiatry Residency Research Education ProgramR25MH112473 · NIMH · WASHINGTON UNIVERSITY · PI NURI B FARBER, Timothy Eric Spiegel · 2018 to 2026
$1.6M
Interdisciplinary Training in Cognitive, Computational and Systems NeuroscienceT32NS073547 · NINDS · WASHINGTON UNIVERSITY · PI BARBOUR, DENNIS L, PETERSEN, STEVEN E. · 2011 to 2015
$850k
PREDICTING OUTCOME IN CHILDREN WITH TIC DISORDERS USING NEUROIMAGING DATAK01MH104592 · NIMH · WASHINGTON UNIVERSITY · PI GREENE, DEANNA JACQUELYN · 2014 to 2018
$723k
Examining vulnerable brain locations using network analysisF32NS092290 · NINDS · WASHINGTON UNIVERSITY · PI GRATTON, CATERINA · 2015 to 2017
$112k
Neuroimaging-based identification of Traumatic Brain Injury subtypesIK2CX001680 · VA · OLIN TEAGUE VETERANS CENTER · PI GORDON, EVAN M. · 2019 to 2021
–
CSRD VA IK2 CX001680NIMH NIH HHS K01 MH104592NIMH NIH HHS R01 MH118370NIMH NIH HHS R25 MH112473NINDS NIH HHS F32 NS092290NINDS NIH HHS T32 NS047987NINDS NIH HHS T32 NS073547
6 · The paper itself

Abstract

Resting-state functional magnetic resonance imaging (fMRI) has provided converging descriptions of group-level functional brain organization. Recent work has revealed that functional networks identified in individuals contain local features that differ from the group-level description. We define these features as network variants. Building on these studies, we ask whether distributions of network variants reflect stable, trait-like differences in brain organization. Across several datasets of highly-sampled individuals we show that 1) variants are highly stable within individuals, 2) variants are found in characteristic locations and associate with characteristic functional networks across large groups, 3) task-evoked signals in variants demonstrate a link to functional variation, and 4) individuals cluster into subgroups on the basis of variant characteristics that are related to differences in behavior. These results suggest that distributions of network variants may reflect stable, trait-like, functionally relevant individual differences in functional brain organization.

Indexed as

BrainBrain MappingHumansMagnetic Resonance ImagingNeural Pathwaysfunctional connectivityindividual differencesnetworksresting-state

Identifiers

PMID31611415
PMCPMC6842602

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.