Evidence map›Paper›PMID 31611408›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

William J Perry, Jeffrey M Spraggins, Jessica R Sheldon, Caroline M Grunenwald, David E Heinrichs, James E Cassat, Eric P Skaar, Richard M Caprioli

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. SLC11A2 withholds divalent metals fromProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. IntracellularProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. mBio · 2025
    Article
  8. SLC11A2 affects nutritional immunity in the gut epithelium.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Understanding the role ofFrontiers in medicine · 2024
    Review
  19. Article
  20. bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

William J PerryMass Spectrometry Research Center, Vanderbilt University, Nashville, TN 37232.ORCID 0000-0002-0570-6956
Jeffrey M SpragginsMass Spectrometry Research Center, Vanderbilt University, Nashville, TN 37232.
Jessica R SheldonVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University, Nashville, TN 37232.ORCID 0000-0002-1413-9404
Caroline M GrunenwaldVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University, Nashville, TN 37232.
David E HeinrichsDepartment of Microbiology and Immunology, University of Western Ontario, London, ON N6A 3K7, Canada.ORCID 0000-0002-7217-2456
James E CassatVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University, Nashville, TN 37232.
Eric P SkaarVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University, Nashville, TN 37232; eric.skaar@vumc.org.
Richard M CaprioliMass Spectrometry Research Center, Vanderbilt University, Nashville, TN 37232.
Vanderbilt University · USWestern University · CA

Funding

Training (pp 214-245)P41GM103391 · NIGMS · VANDERBILT UNIVERSITY · PI SCHEY, KEVIN L · 2012 to 2020
$17.7M
Pathobiology of heme inducible transporters in Gram positive pathogensR01AI073843 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2009 to 2025
$5.9M
Vanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Tissue MappingU54DK120058 · NIDDK · VANDERBILT UNIVERSITY · PI HARRIS, RAYMOND C. · 2018 to 2021
$5.7M
Mechanism and function of heme-iron utilization in staphylococcal pathogenesisR01AI069233 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2006 to 2020
$5.6M
Molecular mapping of microbial communities at the host-pathogen interface by multi-modal 3-dimensional imaging mass spectrometryR01AI138581 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric P Skaar, Jeffrey M Spraggins · 2018 to 2026
$5.2M
The impact of hypoxia on Staphylococcus aureus metabolism and virulence during osteomyelitisR01AI132560 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASSAT, JAMES E · 2017 to 2021
$1.9M
15 Tesla Bruker SolariX FT-ICR mass spectrometerS10OD012359 · OD · VANDERBILT UNIVERSITY · PI CAPRIOLI, RICHARD M · 2012 to 2012
$1.6M
Host-pathogen interactions during osteomyelitisK08AI113107 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASSAT, JAMES E · 2014 to 2018
$885k
Laser Ablation Inductively Coupled Plasma Mass Spectrometer (LA-ICP-MS)S10RR026742 · NCRR · VANDERBILT UNIVERSITY · PI SKAAR, ERIC P · 2011 to 2011
$579k
CIHRNCRR NIH HHS S10 RR026742NIAID NIH HHS K08 AI113107NIAID NIH HHS R01 AI069233NIAID NIH HHS R01 AI073843NIAID NIH HHS R01 AI132560NIAID NIH HHS R01 AI138581NIDDK NIH HHS U54 DK120058NIGMS NIH HHS P41 GM103391NIH HHS S10 OD012359
6 · The paper itself

Abstract

Siderophores, iron-scavenging small molecules, are fundamental to bacterial nutrient metal acquisition and enable pathogens to overcome challenges imposed by nutritional immunity. Multimodal imaging mass spectrometry allows visualization of host-pathogen iron competition, by mapping siderophores within infected tissue. We have observed heterogeneous distributions of

Indexed as

AbscessAnimalsCitratesHost-Pathogen InteractionsIronMiceOrnithineSiderophoresSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationStaphylococcal InfectionsStaphylococcus aureusCitratesIronOrnithineSiderophoresstaphyloferrin Astaphyloferrin Binfectious diseasemetallophoremulitmodal molecular imagingnutritional immunitysiderophore

Identifiers

PMID31611408
PMCPMC6825271
OpenAlexW2981274538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.