Evidence map›Paper›PMID 31611402›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells.

Lisa M McEwen, Kieran J O'Donnell, Megan G McGill, Rachel D Edgar, Meaghan J Jones, Julia L MacIsaac, David Tse Shen Lin, Katia Ramadori, Alexander Morin, Nicole Gladish and 30 more

Registry-linked trialOpen access · bronzeAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06669624 (Leveraging Scientific Advances to Strengthen the Implementation, Evaluation, and Impacts of Intervention Programs for Children Experiencing Early Life Adversity), which is not on this map. Cited by 173 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 2 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06669624 narecruitingnot on this mapstarted 2024, after this paper: background citation

Leveraging Scientific Advances to Strengthen the Implementation, Evaluation, and Impacts of Intervention Programs for Children Experiencing Early Life Adversity

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2024 to 2027Enrolled150ConditionsParenting Intervention, Stress, Caregiver Child Relationship, Child Behavior ProblemArmsAttachment and Biobehavioral Catch-up (ABC), Waitlist with 4-month delay, then ABC
3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 2 syntheses or guidelines pooled it, 278 citations in OpenAlex.

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113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors at 17 institutions in 5 countries.

Lisa M McEwenDepartment of Medical Genetics, University of British Columbia-BC Children's Hospital Research Institute, Vancouver, BC, Canada V5Z 4H4.ORCID 0000-0002-0500-9173
Kieran J O'DonnellDouglas Mental Health University Institute, McGill University, Montreal, QC, Canada H4H 1R3.ORCID 0000-0002-3935-1014
Megan G McGillDouglas Mental Health University Institute, McGill University, Montreal, QC, Canada H4H 1R3.
Rachel D EdgarDepartment of Medical Genetics, University of British Columbia-BC Children's Hospital Research Institute, Vancouver, BC, Canada V5Z 4H4.
Meaghan J JonesDepartment of Medical Genetics, University of British Columbia-BC Children's Hospital Research Institute, Vancouver, BC, Canada V5Z 4H4.ORCID 0000-0003-1593-997X
Julia L MacIsaacDepartment of Medical Genetics, University of British Columbia-BC Children's Hospital Research Institute, Vancouver, BC, Canada V5Z 4H4.
David Tse Shen LinDepartment of Medical Genetics, University of British Columbia-BC Children's Hospital Research Institute, Vancouver, BC, Canada V5Z 4H4.
Katia RamadoriDepartment of Medical Genetics, University of British Columbia-BC Children's Hospital Research Institute, Vancouver, BC, Canada V5Z 4H4.
Alexander MorinDepartment of Medical Genetics, University of British Columbia-BC Children's Hospital Research Institute, Vancouver, BC, Canada V5Z 4H4.
Nicole GladishDepartment of Medical Genetics, University of British Columbia-BC Children's Hospital Research Institute, Vancouver, BC, Canada V5Z 4H4.
Elika GargDouglas Mental Health University Institute, McGill University, Montreal, QC, Canada H4H 1R3.
Eva UnternaehrerDouglas Mental Health University Institute, McGill University, Montreal, QC, Canada H4H 1R3.
Irina PokhvisnevaDouglas Mental Health University Institute, McGill University, Montreal, QC, Canada H4H 1R3.
Neerja KarnaniSingapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR); Singapore 117609.
Michelle Z L KeeSingapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR); Singapore 117609.ORCID 0000-0002-4426-4521
Torsten KlengelDepartment of Psychiatry, Harvard Medical School-McLean Hospital, Belmont, MA 02478.
Nancy E AdlerChild and Brain Development Program, Canadian Institute for Advanced Research (CIFAR) Institute, Toronto, ON, Canada M5G 1M1.ORCID 0000-0001-6962-0724
Ronald G BarrChild and Brain Development Program, Canadian Institute for Advanced Research (CIFAR) Institute, Toronto, ON, Canada M5G 1M1.
Nicole LetourneauAlberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada T2N 4N1.
Gerald F GiesbrechtAlberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada T2N 4N1.
James N ReynoldsDepartment of Biomedical and Molecular Sciences, School of Medicine, Queen's University, Kingston, ON, Canada K7L 3N6.
Darina CzamaraDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Jeffrey M ArmstrongDepartment of Psychiatry, University of Wisconsin-Madison, Madison, WI 53706.
Marilyn J EssexDepartment of Psychiatry, University of Wisconsin-Madison, Madison, WI 53706.
Carolina de WeerthDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, 6525 HR, Nijmegen, The Netherlands.
Roseriet BeijersBehavioural Science Institute, Radboud University, 6525 HR, Nijmegen, The Netherlands.
Marieke S TollenaarLeiden Institute for Brain and Cognition, Institute of Psychology, Leiden University, 2300 RB, Leiden, The Netherlands.
Bekh BradleyDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322.
Tanja JovanovicDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322.
Kerry J ResslerDepartment of Psychiatry, Harvard Medical School-McLean Hospital, Belmont, MA 02478.
Meir SteinerDepartment of Psychiatry and Behavioural Neurosciences, St. Joseph's Healthcare Hamilton, McMaster University, Hamilton, ON, Canada L8S 4L8.
Sonja EntringerCharité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Medical Psychology, 10117 Berlin, Germany.
Pathik D WadhwaDevelopment, Health, and Disease Research Program, University of California, Irvine, CA 92617.
Claudia BussCharité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Medical Psychology, 10117 Berlin, Germany.
Nicole R BushDepartment of Psychiatry, University of California, San Francisco, CA 94143.ORCID 0000-0003-0217-9975
Elisabeth B BinderChild and Brain Development Program, Canadian Institute for Advanced Research (CIFAR) Institute, Toronto, ON, Canada M5G 1M1.ORCID 0000-0001-7088-6618
W Thomas BoyceChild and Brain Development Program, Canadian Institute for Advanced Research (CIFAR) Institute, Toronto, ON, Canada M5G 1M1.
Michael J MeaneyDouglas Mental Health University Institute, McGill University, Montreal, QC, Canada H4H 1R3.
Steve HorvathDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; shorvath@mednet.ucla.edu msk@bcchr.ca.
Michael S KoborDepartment of Medical Genetics, University of British Columbia-BC Children's Hospital Research Institute, Vancouver, BC, Canada V5Z 4H4; shorvath@mednet.ucla.edu msk@bcchr.ca.
University of British Columbia · CACanadian Institute for Advanced Research · CADouglas Mental Health University Institute · CAAgency for Science, Technology and Research · SGEmory University · USHarvard University · USRadboud University Nijmegen · NLUniversity of Calgary · CAUniversity of California, Irvine · USUniversity of Wisconsin–Madison · USHumboldt-Universität zu Berlin · DELeiden University · NLMax Planck Institute of Psychiatry · DEQueen's University · CASt. Joseph’s Healthcare Hamilton · CAUniversity of California, Los Angeles · USUniversity of California, San Francisco · US

Funding

Genetic and Trauma-Related Risk Factors for PTSDR01MH071537 · NIMH · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2005 to 2014
$8.5M
Intergenerational Effects of Maternal Childhood Trauma on the Fetal BrainR01MH105538 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUSS, CLAUDIA, FAIR, DAMIEN A · 2015 to 2019
$3.5M
Validation and optimization of epigenetic clocksU01AG060908 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2018 to 2022
$3.4M
EMA Assessment of Biobehavioral Processes in Human PregnancyR01HD060628 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WADHWA, PATHIK D · 2010 to 2014
$3.4M
Social Ordering and Mental/Physical Health in ChildrenR01MH062320 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI BOYCE, W. THOMAS · 2002 to 2006
$2.9M
Mechanisms of Intergenerational Impact of Maternal TraumaR01HD071982 · NICHD · EMORY UNIVERSITY · PI BRADLEY, BEKH · 2013 to 2017
$2.1M
Development, Trauma, and Genotype Effects on Biomarkers of Anxiety in ChildrenR01MH100122 · NIMH · EMORY UNIVERSITY · PI JOVANOVIC, TANJA · 2013 to 2017
$1.9M
Berkeley Population CenterR21HD056581 · NICHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI HOUT, MICHAEL · 2007 to 2011
$1.2M
The epiGenetIcs Leads to aGe-relAted diseases (GILGA-mesh) NetworkU34AG051425 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HORVATH, STEVE · 2015 to 2017
$954k
Genetic and Trauma-Related Risk Factors for PTSD: From GWAS to FunctionR56MH071537 · NIMH · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2015 to 2015
$148k
NIA NIH HHS U01 AG060908NIA NIH HHS U34 AG051425NICHD NIH HHS R01 HD060628NICHD NIH HHS R01 HD071982NICHD NIH HHS R21 HD056581NIMH NIH HHS R01 MH062320NIMH NIH HHS R01 MH071537NIMH NIH HHS R01 MH100122NIMH NIH HHS R01 MH105538NIMH NIH HHS R56 MH071537
6 · The paper itself

Abstract

The development of biological markers of aging has primarily focused on adult samples. Epigenetic clocks are a promising tool for measuring biological age that show impressive accuracy across most tissues and age ranges. In adults, deviations from the DNA methylation (DNAm) age prediction are correlated with several age-related phenotypes, such as mortality and frailty. In children, however, fewer such associations have been made, possibly because DNAm changes are more dynamic in pediatric populations as compared to adults. To address this gap, we aimed to develop a highly accurate, noninvasive, biological measure of age specific to pediatric samples using buccal epithelial cell DNAm. We gathered 1,721 genome-wide DNAm profiles from 11 different cohorts of typically developing individuals aged 0 to 20 y old. Elastic net penalized regression was used to select 94 CpG sites from a training dataset (

Indexed as

AdolescentAdultChildChild, PreschoolCohort StudiesCpG IslandsEpigenesis, GeneticEpigenomicsEpithelial CellsFemaleHumansInfantLongitudinal StudiesMaleMouth MucosaYoung AdultadolescenceagedevelopmentDNA methylationepigenetic clock

Identifiers

PMID31611402
PMCPMC7519312
OpenAlexW2980520436

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.