ArticleProceedings of the National Academy of Sciences of the United States of America2020
Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Sickness and the Social Brain: Love in the Time of COVID.Frontiers in psychiatry · 2021Pooled it
- Social status impacts T-cell responses through synapse strength in the prefrontal cortex.Cell research · 2026Article
- Adaptive immune responses to vaccination reflect social status at first exposure in female rhesus macaques.bioRxiv : the preprint server for biology · 2026Article
- Effects of Lifelong Low Social Status on Inflammatory Markers in Adult Female Macaques.Biomolecules · 2026Article
- A female-biased gene expression signature of dominance in cooperatively breeding meerkats.Molecular ecology · 2024Article
- Immune cell composition varies by age, sex and exposure to social adversity in free-ranging Rhesus Macaques.GeroScience · 2024Article
- DNA methylation signatures of early-life adversity are exposure-dependent in wild baboons.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Re-wilding model organisms: Opportunities to test causal mechanisms in social determinants of health and aging.Neuroscience and biobehavioral reviews · 2023Review
- Demographic turnover can be a leading driver of hierarchy dynamics, and social inheritance modifies its effects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- DNA methylation signatures of early life adversity are exposure-dependent in wild baboons.bioRxiv : the preprint server for biology · 2023Article
- Human social genomics: Concepts, mechanisms, and implications for health.Lifestyle medicine (Hoboken, N.J.) · 2023Article
- Agonism and grooming behaviour explain social status effects on physiology and gene regulation in rhesus macaques.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- The dynamics of dominance: open questions, challenges and solutions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Distinct gene regulatory signatures of dominance rank and social bond strength in wild baboons.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Holistic Rehabilitation: Biological Embedding of Social Adversity and Its Health Implications.Physical therapy · 2022Article
- Sensitive periods during the development and expression of vertebrate sexual signals: A systematic review.Ecology and evolution · 2021Review
- The Immunology of Stress and the Impact of Inflammation on the Brain and Behavior.BJPsych advances · 2021Article
- Where Are the Disease-Associated eQTLs?Trends in genetics : TIG · 2021Review
- SARS-CoV-2 morbidity and mortality in racial/ethnic minority populations: A window into the stress related inflammatory basis of health disparities?Brain, behavior, & immunity - health · 2020Review
- Rhesus macaques as a tractable physiological model of human ageing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Social experience is an important predictor of disease susceptibility and survival in humans and other social mammals. Chronic social stress is thought to generate a proinflammatory state characterized by elevated antibacterial defenses and reduced investment in antiviral defense. Here we manipulated long-term social status in female rhesus macaques to show that social subordination alters the gene expression response to ex vivo bacterial and viral challenge. As predicted by current models, bacterial lipopolysaccharide polarizes the immune response such that low status corresponds to higher expression of genes in NF-κB-dependent proinflammatory pathways and lower expression of genes involved in the antiviral response and type I IFN signaling. Counter to predictions, however, low status drives more exaggerated expression of both NF-κB- and IFN-associated genes after cells are exposed to the viral mimic Gardiquimod. Status-driven gene expression patterns are linked not only to social status at the time of sampling, but also to social history (i.e., past social status), especially in unstimulated cells. However, for a subset of genes, we observed interaction effects in which females who fell in rank were more strongly affected by current social status than those who climbed the social hierarchy. Taken together, our results indicate that the effects of social status on immune cell gene expression depend on pathogen exposure, pathogen type, and social history-in support of social experience-mediated biological embedding in adulthood, even in the conventionally memory-less innate immune system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.