ArticleProceedings of the National Academy of Sciences of the United States of America2019
Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection.
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In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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0cells of the map it votes in
65citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 99 citations in OpenAlex.
- Coordinated control of proteasome subunit gene expression promotes stress resistance, proteostasis, and longevity.GeroScience · 2026Article
- Metabolic shifts driven by host-microbial interactions.The FEBS journal · 2026Review
- Ribonuclease DIS3 delays aging and senescence by generating tRNA halves.Nature communications · 2026Article
- Article
- Suppression of the fat storage defect ofmicroPublication biology · 2026Article
- Enhanced oxidative stress resilience inExperimental biology and medicine (Maywood, N.J.) · 2026Article
- 6-PPD induces mitochondrial dysfunction and reduces healthspan and lifespan through SKN-1 in Caenorhabditis elegans.Journal of hazardous materials · 2025Article
- LIPL-1 and LIPL-2 are TCER-1-regulated lysosomal lipases with distinct roles in immunity and fertility.PLoS genetics · 2025Article
- Parental age selection in C. elegans influences progeny stress resistance capacity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Host Transcriptomics Reveal Reduction in Defence-Reproduction Trade-Offs During Coinfection.Molecular ecology · 2025Article
- BMP-dependent mobilization of fatty acid metabolism promotes Caenorhabditis elegans survival on a bacterial pathogen.Disease models & mechanisms · 2025Article
- Patterns of pathogenesis in innate immunity: insights from C. elegans.Nature reviews. Immunology · 2025Review
- Protein sequence editing defines distinct and overlapping functions of SKN-1A/Nrf1 and SKN-1C/Nrf2.PLoS genetics · 2025Article
- An inducible and reversible system to regulate unsaturated fatty acid biosynthesis in C. elegans.G3 (Bethesda, Md.) · 2025Article
- Activated SKN-1 alters the aging trajectories of long-lived Caenorhabditis elegans mutants.Genetics · 2025Article
- Differential impacts of ribosomal protein haploinsufficiency on mitochondrial function.The Journal of cell biology · 2025Article
- Article
- Microsporidia infection alters C. elegans lipid levels.PloS one · 2025Article
- Lysosome-related organelle integrity suppresses TIR-1 aggregation to restrain toxic propagation of p38 innate immunity.Cell reports · 2024Article
- Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy.Nature communications · 2024Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
James D NhanLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089.
Christian D TurnerLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089.
Sarah M AndersonProgram in Innate Immunity, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01655.
Chia-An YenLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089.
Hans M DaltonLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089.
Hilary K CheesmanProgram in Innate Immunity, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01655.
Dana L RuterBiology Department, Integrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC 27599.
Nandhitha Uma NareshDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01655.
Cole M HaynesDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01655.
Alexander A SoukasCenter for Human Genetic Research and Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114.ORCID 0000-0002-9100-2436
Read Pukkila-WorleyProgram in Innate Immunity, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01655; Read.Pukkila-Worley@umassmed.edu spcurran@usc.edu.
Sean P CurranLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089; Read.Pukkila-Worley@umassmed.edu spcurran@usc.edu.ORCID 0000-0001-7791-6453
University of Massachusetts Chan Medical School · USUniversity of Southern California · USMassachusetts General Hospital · USUniversity of North Carolina at Chapel Hill · US
Funding
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6MRESEARCH TRAINING IN GERONTOLOGYT32AG000037 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE, EILEEN M CRIMMINS · 1985 to 2026
$13.2MEnhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5MAn Immune Surveillance Network in C. elegansR01AI130289 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI PUKKILA-WORLEY, READ · 2017 to 2025
$4.6MTRAINING IN IMMUNOLOGY (COMPETITIVE RENEWAL OF AI07439)T32AI007349 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STERN, LAWRENCE J. · 1989 to 2024
$4.5MGenetic mechanisms of metformin's pro-longevity and anti-cancer effectsR01AG058256 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI SOUKAS, ALEXANDER A · 2018 to 2022
$3.0MAge-dependent SKN-1/NRF cytoprotection at the cost of metabolic homeostasisR01AG058610 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CURRAN, SEAN P · 2019 to 2023
$2.1MNovel roles for Maf1 as a central regulator of lipid homeostasisR01GM109028 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CURRAN, SEAN P · 2014 to 2018
$1.8MCBI: Chemistry Biology InterfaceT32GM118289 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FORSBURG, SUSAN L · 2016 to 2020
$1.2MExploiting a gain-of-function SKN-1 mutant to discover novel mechanisms of transcription factor regulationF31GM137587 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TURNER, CHRISTIAN DAVID · 2020 to 2022
$138kCharacterization of Conserved Protein Synthesis Aging PathwaysF31AG051382 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DALTON, HANS MARTIN · 2016 to 2018
$87kNIAID NIH HHS R01 AI130289NIAID NIH HHS T32 AI007349NIA NIH HHS F31 AG051382NIA NIH HHS R01 AG058256NIA NIH HHS R01 AG058610NIA NIH HHS T32 AG000037NIDDK NIH HHS P30 DK040561NIGMS NIH HHS F31 GM137587NIGMS NIH HHS R01 GM109028NIGMS NIH HHS T32 GM118289NIH HHS P40 OD010440
Abstract
Early host responses toward pathogens are essential for defense against infection. In
Indexed as
Epigenesis, GeneticLipid MetabolismAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsDNA-Binding ProteinsImmunity, InnateMAP Kinase Signaling SystemOxidative Stressp38 Mitogen-Activated Protein KinasesPseudomonas aeruginosaPseudomonas InfectionsTranscription FactorsTranscriptomeCaenorhabditis elegans ProteinsDNA-Binding Proteinsp38 Mitogen-Activated Protein Kinasesskn-1 protein, C elegansTranscription FactorsC. elegansH3K4me3lipid metabolismpathogenSKN-1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.