ArticleOccupational and environmental medicine2019
Parental occupational exposure to diesel engine exhaust in relation to childhood leukaemia and central nervous system cancers: a register-based nested case-control study in Denmark 1968-2016.
Article in Occupational and environmental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Occupational Diesel Exposure and Brain Tumors: A Systematic Review and Meta-Analysis.La Medicina del lavoro · 2025Pooled it
- Occupational-related exposure to diesel exhaust and risk of leukemia: systematic review and meta-analysis of cohort studies.International archives of occupational and environmental health · 2024Pooled it
- Risk factors for childhood brain tumours: A systematic review and meta-analysis of observational studies from 1976 to 2022.Cancer epidemiology · 2024Pooled it
- Causes of Childhood Cancer: A Literature Review (2014-2021)-Part 3: Environmental and Occupational Factors.Cancers · 2025Review
- Maternal Exposure to Heavy Metals From Industrial Sources During Pregnancy and Childhood Cancer Risk in California.Journal of occupational and environmental medicine · 2024Article
- Maternal residential exposure to solvents from industrial sources during pregnancy and childhood cancer risk in California.International journal of hygiene and environmental health · 2024Article
- Environmental Pollution and Risk of Childhood Cancer: A Scoping Review of Evidence from the Last Decade.International journal of molecular sciences · 2024Article
- Environmental, social and behavioral risk factors in association with spatial clustering of childhood cancer incidence.Spatial and spatio-temporal epidemiology · 2023Article
- Parental occupational exposure to combustion products, metals, silica and asbestos and risk of childhood leukaemia: Findings from the Childhood Cancer and Leukaemia International Consortium (CLIC).Environment international · 2022Article
- Risk of Cancer in Children of Parents Occupationally Exposed to Hydrocarbon Solvents and Engine Exhaust Fumes: A Register-Based Nested Case-Control Study from Sweden (1960-2015).Environmental health perspectives · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesUsing nationwide register data, we investigated the association between maternal and paternal perinatal employment in industries with exposure to diesel engine exhaust and risk of leukaemia and central nervous system (CNS) cancers, including certain subtypes.
methodsChildren aged≤19 years and diagnosed with childhood cancer from 1968 to 2016 were identified in the Danish Cancer Registry and 25 randomly selected cancer-free controls per case were matched by age and sex. Parents were identified in the Danish Civil Registration System and employment histories were retrieved from a nationwide mandatory pension fund. The probability of exposure to diesel engine exhaust was assessed using a validated job exposure matrix. Conditional logistic regression was used for estimation of ORs, including their 95% CIs.
resultsMaternal employment in industries with diesel engine exhaust exposure was associated with an increased risk of CNS cancers (OR 1.31, 95% CI 0.99 to 1.74) and of astrocytoma (OR 1.49, 95% CI 1.04 to 2.14) in offspring. The highest OR for these cancers were seen for mothers with highest probability of exposure to diesel engine exhaust. For fathers, ORs for cancers under study were close to one. No increased risks of leukaemias were found for either mothers or fathers employed in diesel industries.
conclusionsRisks were increased for CNS and astrocytoma for maternal employment in industries with diesel engine exhaust.
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