Evidence map›Paper›PMID 31611261›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

RELMα Licenses Macrophages for Damage-Associated Molecular Pattern Activation to Instigate Pulmonary Vascular Remodeling.

Qing Lin, Chunling Fan, John T Skinner, Elizabeth N Hunter, Andrew A Macdonald, Peter B Illei, Kazuyo Yamaji-Kegan, Roger A Johns

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Human Resistin Induces Cardiac Dysfunction in Pulmonary Hypertension.Journal of the American Heart Association · 2023
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Qing LinDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205; and.
Chunling FanDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205; and.
John T SkinnerDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205; and.ORCID 0000-0002-0752-5438
Elizabeth N HunterDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205; and.
Andrew A MacdonaldDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205; and.
Peter B IlleiDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0003-4440-9265
Kazuyo Yamaji-KeganDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205; and.ORCID 0000-0002-8500-972X
Roger A JohnsDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205; and rajohns@jhmi.edu.ORCID 0000-0001-9232-2434
Johns Hopkins University · US

Funding

Targeting resitin and RELM-beta to treat pulmonary hypertensionUH3HL123827 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI JOHNS, ROGER A · 2016 to 2018
$4.9M
Targeting resitin and RELM-beta to treat pulmonary hypertensionUH2HL123827 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI JOHNS, ROGER A · 2014 to 2015
$3.1M
REGULATION OF NO SIGNALING IN PULMONARY VASCULATURER01HL039706 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI JOHNS, ROGER A · 1993 to 2006
$2.4M
Insulin Receptor Substrate Signaling in Pulmonary HypertensionR01HL135022 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI KEEGAN, ACHSAH D. · 2018 to 2022
$2.0M
DAMP Signaling Mediates HIMF-induced Pulmonary HypertensionR01HL138497 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI JOHNS, ROGER A · 2018 to 2021
$1.8M
Targeting resitin and RELM-beta to treat pulmonary hypertensionP50HL107182 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI JOHNS, ROGER A · 2011 to 2012
$983k
NHLBI NIH HHS P50 HL107182NHLBI NIH HHS R01 HL039706NHLBI NIH HHS R01 HL135022NHLBI NIH HHS R01 HL138497NHLBI NIH HHS UH2 HL123827NHLBI NIH HHS UH3 HL123827
6 · The paper itself

Abstract

Pulmonary hypertension (PH) is a debilitating disease characterized by remodeling of the lung vasculature. In rodents, resistin-like molecule-α (RELMα, also known as HIMF or FIZZ1) can induce PH, but the signaling mechanisms are still unclear. In this study, we used human lung samples and a hypoxia-induced mouse model of PH. We found that the human homolog of RELMα, human (

Indexed as

AdolescentAnimalsCells, CulturedHumansHypertension, PulmonaryIntercellular Signaling Peptides and ProteinsMacrophages, AlveolarMiceMice, Inbred C57BLMice, KnockoutPulmonary ArteryVascular RemodelingIntercellular Signaling Peptides and Proteinsresistin-like alpha protein, human

Identifiers

PMID31611261
PMCPMC6864303
OpenAlexW2980921757

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.