Evidence map›Paper›PMID 31611232›Full record

ArticleGenetics2019

Specific Residues in a Purine Transporter Are Critical for Dimerization, ER Exit, and Function.

Anezia Kourkoulou, Pothos Grevias, George Lambrinidis, Euan Pyle, Mariangela Dionysopoulou, Argyris Politis, Emmanuel Mikros, Bernadette Byrne, George Diallinas

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Anezia KourkoulouDepartment of Biology, National and Kapodistrian University of Athens, Panepistimioupolis, 15784, Greece.
Pothos GreviasDepartment of Biology, National and Kapodistrian University of Athens, Panepistimioupolis, 15784, Greece.ORCID 0000-0002-7070-4148
George LambrinidisDepartment of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis, 15771, Greece.ORCID 0000-0002-2820-9338
Euan PyleDepartment of Life Sciences, Imperial College London, SW7 2AZ, UK.
Mariangela DionysopoulouDepartment of Biology, National and Kapodistrian University of Athens, Panepistimioupolis, 15784, Greece.
Argyris PolitisDepartment of Chemistry, King's College London, SE1 1DB, UK.
Emmanuel MikrosDepartment of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis, 15771, Greece.
Bernadette ByrneDepartment of Life Sciences, Imperial College London, SW7 2AZ, UK.
George DiallinasDepartment of Biology, National and Kapodistrian University of Athens, Panepistimioupolis, 15784, Greece diallina@biol.uoa.gr.ORCID 0000-0002-3426-726X
National and Kapodistrian University of Athens · GRKing's College London · GBImperial College London · GB

Funding

Biotechnology and Biological Sciences Research Council B.B./N016467/1
6 · The paper itself

Abstract

Transporters are transmembrane proteins that mediate the selective translocation of solutes across biological membranes. Recently, we have shown that specific interactions with plasma membrane phospholipids are essential for the formation and/or stability of functional dimers of the purine transporter UapA, a prototypic eukaryotic member of the ubiquitous nucleobase ascorbate transporter (NAT) family. Here, we provide strong evidence that distinct interactions of UapA with membrane lipids are essential for

Indexed as

Protein MultimerizationAmino Acid SubstitutionAspergillus nidulansEndoplasmic ReticulumFungal ProteinsLipidsMembrane Transport ProteinsMolecular Dynamics SimulationMutant ProteinsProtein DomainsProtein StabilityStructure-Activity RelationshipSuppression, GeneticFungal ProteinsLipidsMembrane Transport ProteinsMutant ProteinsAspergillus nidulansNATnucleobaserSNBT1UapA

Identifiers

PMID31611232
PMCPMC6893392
OpenAlexW2980551955

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.