ArticleThe Journal of thoracic and cardiovascular surgery2020
Long-term, disease-specific outcomes of thymic malignancies presenting with de novo pleural metastasis.
Article in The Journal of thoracic and cardiovascular surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Long-Term Outcomes of Surgery for Thymic Epithelial Tumors With Pleural Metastases.JTO clinical and research reports · 2026Article
- Long-Term Outcomes of Surgical Resection for Thymic Epithelial Tumour With Intrathoracic Dissemination.Interdisciplinary cardiovascular and thoracic surgery · 2026Article
- Novel strategies in radiation therapy: high-dose radiotherapy for oligometastatic/oligo-progressive thymic tumors.Mediastinum (Hong Kong, China) · 2026Review
- A real-world cohort study comparing chemotherapy and surgery in the treatment of stage IVA thymomas with pleural dissemination.Mediastinum (Hong Kong, China) · 2026Article
- Management of liver metastases secondary to thymic epithelial tumors: a narrative review of current management and future directions.Mediastinum (Hong Kong, China) · 2026Review
- Therapeutic Management of Metastatic Thymoma and Thymic Carcinoma.Current oncology reports · 2025Review
- Managing stage IV thymic carcinoma-a narrative review of radiation therapy strategies and options.Mediastinum (Hong Kong, China) · 2025Review
- Surveillance of thymic epithelial tumors (TETs)-a narrative review.Mediastinum (Hong Kong, China) · 2025Review
- Spatial Distribution Patterns of Pleural Dissemination in Patients With Thymoma and Survival Analysis.Canadian respiratory journal · 2024Article
- Surgical treatment of thymic epithelial tumors: a narrative review.Mediastinum (Hong Kong, China) · 2024Review
- Relevance of robotic surgery for thymoma: a narrative review.Mediastinum (Hong Kong, China) · 2024Review
- Managing recurrent thymic epithelial tumors after resection: outcomes and role of re-resection.Mediastinum (Hong Kong, China) · 2024Review
- American Radium Society Appropriate Use Criteria for Radiation Therapy in the Multidisciplinary Management of Thymic Carcinoma.JAMA oncology · 2023Review
- Thymic Carcinomas-A Concise Multidisciplinary Update on Recent Developments From the Thymic Carcinoma Working Group of the International Thymic Malignancy Interest Group.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2022Review
- Radiation strategy and techniques for metastatic pleural disease from thymic malignancies: extended abstract.Mediastinum (Hong Kong, China) · 2022Article
- Surgical management of locally advanced thymic neoplasms.Mediastinum (Hong Kong, China) · 2022Article
- Occult pleural dissemination detected intraoperatively in patients with thymic tumors: a retrospective analysis.Journal of cardiothoracic surgery · 2021Article
- The role of surgery in the management of locally advanced and metastatic thymoma: a narrative review.Mediastinum (Hong Kong, China) · 2021Review
- Indolent stage IVA thymic malignancies managed with multimodality treatments.Mediastinum (Hong Kong, China) · 2020Article
- Aggressive surgical therapy in late stage thymoma: durable long-term control of disease.Mediastinum (Hong Kong, China) · 2020Article
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11 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTreatment of patients with thymic malignancies metastatic to the pleura or pericardium is challenging, and benefits of aggressive treatment are unclear. We sought to characterize the long-term outcomes in this population.
methodsWe retrospectively identified patients who underwent resection for de novo thymic malignancies metastatic to the pleura between May 1997 and December 2017. Patients with pleural recurrence after prior thymectomy were excluded. Patient demographics, perioperative treatments, pathologic findings, and postoperative outcomes were collected. Descriptive statistics and Kaplan-Meier analyses were performed.
resultsSeventy-two patients were included (median age, 51 years [range 25-80]; 36/72 women [50%]). Pathologic diagnosis was thymoma in 57 patients (79%) and thymic carcinoma in 15 patients (21%). Most patients (67/72; 93%) received chemotherapy, radiation, or both. Forty-eight patients underwent thymectomy with pleurectomy, 7 patients underwent extrapleural pneumonectomy, 10 patients underwent thymectomy alone, and 7 patients were unresectable. Macroscopic complete resection was achieved in 52 patients (73%). Five-, 10-, and 15-year overall survivals were 73%, 51%, and 18%, respectively, and median overall survival was 11 years (median follow-up, 5.9 years). Forty-six patients (64%) had disease progression (median time to progression, 2.2 years). Repeat episodes of progression and treatment were common (median, 3 episodes/patient). The longest disease-free interval was 12.4 years. Thirteen patients (18%) remain disease-free; 7 patients (10%) were disease-free for more than 5 years. The longest ongoing survival without progression or reintervention is 9.9 years.
conclusionsProlonged survival and, in some cases, cure can be achieved in patients with thymic malignancies metastatic to the pleura or pericardium. Aggressive multimodality therapy may be appropriate for select patients.
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