Evidence map›Paper›PMID 31610866›Full record

ReviewCurrent topics in membranes2019

Structural and signaling role of lipids in plasma membrane repair.

Adam Horn, Jyoti K Jaiswal

Open access · greenAbstract readReview
In one paragraph

Review in Current topics in membranes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 96 citations in OpenAlex.

  1. Review
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  15. Observational
  16. Biosynthesis of lanosterol inSynthetic and systems biotechnology · 2025
    Article
  17. Review
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  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Adam HornChildren's National Health System, Center for Genetic Medicine Research, Washington, DC, United States.
Jyoti K JaiswalChildren's National Health System, Center for Genetic Medicine Research, Washington, DC, United States; Department of Genomics and Precision Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, United States. Electronic address: jkjaiswal@cnmc.org.
Children's National · US

Funding

Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VITTORIO GALLO, VITTORIO GALLO VITTORIO GALLO · 2016 to 2020
$5.9M
Understanding the mechanism and role of cell membrane repair in Miyoshi MyopathyR01AR055686 · NIAMS · ROCKEFELLER UNIVERSITY · PI JAISWAL, JYOTI K · 2008 to 2021
$3.6M
Genetics and Genomics of Muscle Postdoctoral Training ProgramT32AR056993 · NIAMS · CHILDREN'S RESEARCH INSTITUTE · PI JAISWAL, JYOTI K, PARTRIDGE, TERENCE A · 2010 to 2019
$2.2M
NIAMS NIH HHS R01 AR055686NIAMS NIH HHS T32 AR056993NICHD NIH HHS U54 HD090257
6 · The paper itself

Abstract

The plasma membrane forms the physical barrier between the cytoplasm and extracellular space, allowing for biochemical reactions necessary for life to occur. Plasma membrane damage needs to be rapidly repaired to avoid cell death. This relies upon the coordinated action of the machinery that polarizes the repair response to the site of injury, resulting in resealing of the damaged membrane and subsequent remodeling to return the injured plasma membrane to its pre-injury state. As lipids comprise the bulk of the plasma membrane, the acts of injury, resealing, and remodeling all directly impinge upon the plasma membrane lipids. In addition to their structural role in shaping the physical properties of the plasma membrane, lipids also play an important signaling role in maintaining plasma membrane integrity. While much attention has been paid to the involvement of proteins in the membrane repair pathway, the role of lipids in facilitating plasma membrane repair remains poorly studied. Here we will discuss the current knowledge of how lipids facilitate plasma membrane repair by regulating membrane structure and signaling to coordinate the repair response, and will briefly note how lipid involvement extends beyond plasma membrane repair to the tissue repair response.

Indexed as

Signal TransductionAnimalsCell MembraneHumansMembrane LipidsMolecular StructureMembrane LipidsLipidsMembrane injuryPlasma membraneTissue repair

Identifiers

PMID31610866
PMCPMC7182362
OpenAlexW2964206752

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.