Evidence map›Paper›PMID 31610780›Full record

ArticleBMC genomics2019

Acute systemic inflammatory response to lipopolysaccharide stimulation in pigs divergently selected for residual feed intake.

Haibo Liu, Kristina M Feye, Yet T Nguyen, Anoosh Rakhshandeh, Crystal L Loving, Jack C M Dekkers, Nicholas K Gabler, Christopher K Tuggle

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Impacts of F18Animals : an open access journal from MDPI · 2023
    Review
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Haibo LiuDepartment of Animal Science, Iowa State University, 2258 Kildee Hall, Ames, IA, 50011, USA.
Kristina M FeyeInterdepartmental Immunobiology, Department of Animal Science, Iowa State University, 2258 Kildee Hall, Ames, IA, 50011, USA.
Yet T NguyenDepartment of Mathematics and Statistics, Old Dominion University, Norfolk, VA, 23529, USA.
Anoosh RakhshandehDepartment of Animal and Food Sciences, Texas Tech University, Lubbock, TX, 79409, USA.
Crystal L LovingFood Safety and Enteric Pathogens Research Unit, National Animal Disease Center, ARS, USDA, 1920 Dayton Ave, Ames, IA, 50010, USA.
Jack C M DekkersDepartment of Animal Science, Iowa State University, 239 Kildee Hall, Ames, IA, 50011, USA.
Nicholas K GablerDepartment of Animal Science, Iowa State University, 239 Kildee Hall, Ames, IA, 50011, USA.
Christopher K TuggleDepartment of Animal Science, Iowa State University, 2255 Kildee Hall, Ames, IA, 50011, USA. cktuggle@iastate.edu.ORCID http://orcid.org/0000-0002-4229-5316
Iowa State University · USNational Animal Disease Center · USOld Dominion University · USTexas Tech University · US

Funding

National Institute of Food and Agriculture NIFA-AFRI-2011-68004-30336
6 · The paper itself

Abstract

backgroundIt is unclear whether improving feed efficiency by selection for low residual feed intake (RFI) compromises pigs' immunocompetence. Here, we aimed at investigating whether pig lines divergently selected for RFI had different inflammatory responses to lipopolysaccharide (LPS) exposure, regarding to clinical presentations and transcriptomic changes in peripheral blood cells.

resultsLPS injection induced acute systemic inflammation in both the low-RFI and high-RFI line (n = 8 per line). At 4 h post injection (hpi), the low-RFI line had a significantly lower (p = 0.0075) mean rectal temperature compared to the high-RFI line. However, no significant differences in complete blood count or levels of several plasma cytokines were detected between the two lines. Profiling blood transcriptomes at 0, 2, 6, and 24 hpi by RNA-sequencing revealed that LPS induced dramatic transcriptional changes, with 6296 genes differentially expressed at at least one time point post injection relative to baseline in at least one line (n = 4 per line) (|log

conclusionsThe pig lines divergently selected for RFI had a largely similar response to LPS stimulation. However, the low-RFI line had a relatively lower-level, but longer-lasting, inflammatory response compared to the high-RFI line. Our results suggest selection for feed efficient pigs does not significantly compromise a pig's acute systemic inflammatory response to LPS, although slight differences in intensity and duration may occur.

Indexed as

Animal FeedAnimal Nutritional Physiological PhenomenaAnimalsGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksLipopolysaccharidesQuantitative Trait LociSequence Analysis, RNASus scrofaSwineSystemic Inflammatory Response SyndromeLipopolysaccharidesLipopolysaccharideResidual feed intakeRNA-seqSus scrofaSystemic inflammation

Identifiers

PMID31610780
PMCPMC6792331
OpenAlexW2980222389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.