ArticleCirculation research2019
Bone Marrow-Derived Cells Restore Functional Integrity of the Gut Epithelial and Vascular Barriers in a Model of Diabetes and ACE2 Deficiency.
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Article in Circulation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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54citing papers in PubMed, 1 pooled it
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Clinical trials targeting the gut-microbiome to effect ocular health: a systematic review.Eye (London, England) · 2023Pooled it
- Gram-Negative Bacterial Overgrowth Predominated by: Potential Association with Intestinal Barrier Impairment and Inflammatory Diarrhea in Cats.Veterinary sciences · 2026Article
- Resilient Calvarial Bone Marrow Supports Retinal Repair in Type 2 Diabetes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Rosmarinic acid mitigates stress-induced gastric ulcers by targeting the ACE2/GPX4 interaction.Frontiers in pharmacology · 2026Article
- Angiotensin‑converting enzyme 2 expression in human tumors: Implications for prognosis and therapy (Review).Oncology reports · 2025Review
- Angiogenic Factors and Inflammatory Bowel Diseases.Biomedicines · 2025Review
- Article
- Pericyte-derived extracellular vesicles improve vascular barrier function in sepsis via the Angpt1/PI3K/AKT pathway and pericyte recruitment: an in vivo and in vitro study.Stem cell research & therapy · 2025Article
- Bibliometric and visual analysis of ACE2/Ang 1-7/MasR axis in diabetes and its microvascular complications from 2000 to 2023.Heliyon · 2024Article
- Mendelian randomization analysis reveals a causal effect of Streptococcus salivarius on diabetic retinopathy through regulating host fasting glucose.Journal of cellular and molecular medicine · 2024Article
- NOD1 deficiency ameliorates the progression of diabetic retinopathy by modulating bone marrow-retina crosstalk.Stem cell research & therapy · 2024Article
- Integrated analysis of gut microbiome and its metabolites in ACE2-knockout and ACE2-overexpressed mice.Frontiers in cellular and infection microbiology · 2024Article
- Treatment with Ligilactobacillus murinus lowers blood pressure and intestinal permeability in spontaneously hypertensive rats.Scientific reports · 2023Article
- Intestinal Permeability in Patients Early after Kidney Transplantation Treated with Two Different Formulations of Once-Daily Tacrolimus.International journal of molecular sciences · 2023Article
- Intestinal barrier dysfunction as a key driver of severe COVID-19.World journal of virology · 2023Review
- Review
- Sustained ACE2 Expression by Probiotic Improves Integrity of Intestinal Lymphatics and Retinopathy in Type 1 Diabetic Model.Journal of clinical medicine · 2023Article
- Maintenance of Enteral ACE2 Prevents Diabetic Retinopathy in Type 1 Diabetes.Circulation research · 2023Article
- The gut-retina axis: a new perspective in the prevention and treatment of diabetic retinopathy.Frontiers in endocrinology · 2023Review
- The gut microbiota-brain axis in neurological disorder.Frontiers in neuroscience · 2023Review
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Authors and funding
19 authors at 9 institutions in 4 countries.
Yaqian DuanFrom the Department of Anatomy, Cell Biology and Physiology (Y.D., A.G.O.), Indiana University School of Medicine, Indianapolis.
Ram PrasadDepartment of Ophthalmology and Visual Sciences (R.P., S.L.C., A.L.F.L., J.L.F., M.D., S.K.N., M.B.G.), University of Alabama at Birmingham.
Dongni FengDepartment of Ophthalmology, The Eugene and Marilyn Glick Eye Institute (D.F., E.B.), Indiana University School of Medicine, Indianapolis.
Eleni BeliDepartment of Ophthalmology, The Eugene and Marilyn Glick Eye Institute (D.F., E.B.), Indiana University School of Medicine, Indianapolis.
Sergio Li CalziDepartment of Ophthalmology and Visual Sciences (R.P., S.L.C., A.L.F.L., J.L.F., M.D., S.K.N., M.B.G.), University of Alabama at Birmingham.
Ana Leda F LonghiniDepartment of Ophthalmology and Visual Sciences (R.P., S.L.C., A.L.F.L., J.L.F., M.D., S.K.N., M.B.G.), University of Alabama at Birmingham.
Regina LamendellaOhio State University, Wright Labs, LLC, Huntingdon, PA (R.L., J.W.).
Jason L FloydDepartment of Ophthalmology and Visual Sciences (R.P., S.L.C., A.L.F.L., J.L.F., M.D., S.K.N., M.B.G.), University of Alabama at Birmingham.
Mariana DupontDepartment of Ophthalmology and Visual Sciences (R.P., S.L.C., A.L.F.L., J.L.F., M.D., S.K.N., M.B.G.), University of Alabama at Birmingham.
Sunil K NoothiDepartment of Ophthalmology and Visual Sciences (R.P., S.L.C., A.L.F.L., J.L.F., M.D., S.K.N., M.B.G.), University of Alabama at Birmingham.
Gopalkrishna SreejitDepartment of Surgery (G.K.S., B.A., P.R.N.).
Baskaran AthmanathanDepartment of Surgery (G.K.S., B.A., P.R.N.).
Justin WrightOhio State University, Wright Labs, LLC, Huntingdon, PA (R.L., J.W.).
Amanda R JensenRiley Hospital for Children, Pediatric Surgery (A.R.J., T.A.M.), Indiana University School of Medicine, Indianapolis.
Gavin Y OuditOhio State University, Wright Labs, LLC, Huntingdon, PA (R.L., J.W.).
Troy A MarkelRiley Hospital for Children, Pediatric Surgery (A.R.J., T.A.M.), Indiana University School of Medicine, Indianapolis.
Prabhakara R NagareddyDepartment of Surgery (G.K.S., B.A., P.R.N.).
Alexander G ObukhovFrom the Department of Anatomy, Cell Biology and Physiology (Y.D., A.G.O.), Indiana University School of Medicine, Indianapolis.
Maria B GrantDepartment of Ophthalmology and Visual Sciences (R.P., S.L.C., A.L.F.L., J.L.F., M.D., S.K.N., M.B.G.), University of Alabama at Birmingham.
University of Alabama at Birmingham · USWright State University · USIndiana University School of MedicineNorwegian Womens Public Health Association · NODalian Medical University · CNHypertension Institute · USIndiana University – Purdue University Indianapolis · USRamakrishna Mission Vidyamandira · INRiley Hospital for Children · US
Funding
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Stuart J Frank · 2013 to 2026
$19.5MVisual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LAWRENCE C SINCICH · 1985 to 2026
$16.9MNITRIC OXIDE IN THE PATHOGENESIS OF DIABETIC RETINOPATHYR01EY012601 · NEI · UNIVERSITY OF FLORIDA · PI Julia V Busik, Maria Bartolomeo Grant · 1998 to 2026
$9.6MUAB Pre-Doctoral Training Program in Obesity-Related ResearchT32HL105349 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2010 to 2026
$5.7MLXR as a Novel Therapeutic Target in Diabetic RetinopathyR01EY025383 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BUSIK, JULIA V, GRANT, MARIA BARTOLOMEO · 2015 to 2024
$4.2MThrombocytopoiesis in Diabetes: Role of Damage Associated Molecular PatternsR01HL137799 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI NAGAREDDY, PRABHAKARA REDDY · 2018 to 2022
$3.2MTRPC Channels in the Metabolic SyndromeR01HL115140 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI OBUKHOV, ALEXANDER G. · 2012 to 2016
$2.6MSomatostatin blockade of CNS autonomic hyperactivity for treatment of diabetic retinopathyR01EY028037 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOULTON, MICHAEL EDWIN, FRAZIER, CHARLES J · 2017 to 2020
$1.9MACE2 Modulates the Bone Marrow- Gut Axis in Diabetic RetinopathyR01EY028858 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOULTON, MICHAEL EDWIN, GRANT, MARIA BARTOLOMEO · 2018 to 2021
$1.6MUAB Predoctoral Training Program in Lung DiseasesT32HL134640 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SWORDS, WILLIAM E · 2017 to 2021
$1.0MMechanisms of Monocytosis in Obesity:Implications for Cardiovascular DiseaseR00HL122505 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NAGAREDDY, PRABHAKARA REDDY · 2016 to 2018
$740kMechanisms of Monocytosis in Obesity:Implications for Cardiovascular DiseaseK99HL122505 · NHLBI · UNIVERSITY OF KENTUCKY · PI NAGAREDDY, PRABHAKARA REDDY · 2014 to 2015
$176kNEI NIH HHS P30 EY003039NEI NIH HHS R01 EY012601NEI NIH HHS R01 EY025383NEI NIH HHS R01 EY028037NEI NIH HHS R01 EY028858NHLBI NIH HHS K99 HL122505NHLBI NIH HHS R00 HL122505NHLBI NIH HHS R01 HL115140NHLBI NIH HHS R01 HL137799NHLBI NIH HHS T32 HL105349NHLBI NIH HHS T32 HL134640NIDDK NIH HHS P30 DK079626
Abstract
rationaleThere is incomplete knowledge of the impact of bone marrow cells on the gut microbiome and gut barrier function.
objectiveWe postulated that diabetes mellitus and systemic ACE2 (angiotensin-converting enzyme 2) deficiency would synergize to adversely impact both the microbiome and gut barrier function. METHODS AND
resultsBacterial 16S rRNA sequencing and metatranscriptomic analysis were performed on fecal samples from wild-type, ACE2
conclusionsWe demonstrate for the first time that the defect in gut barrier function and dysbiosis in ACE2
Indexed as
Bone Marrow TransplantationCapillary PermeabilityGastrointestinal MicrobiomeNeovascularization, PhysiologicAdherens JunctionsADP-Ribosylation Factor 6Angiotensin-Converting Enzyme 2AnimalsBacteriaCells, CulturedDiabetes Mellitus, Type 2Disease Models, AnimalDysbiosisHumansInflammation MediatorsIntestinal MucosaACE2 protein, humanAce2 protein, mouseADP-Ribosylation Factor 6Angiotensin-Converting Enzyme 2ARF6 protein, humanArf6 protein, mouseInflammation MediatorsPeptidoglycanPeptidyl-Dipeptidase AACE2bone marrowdiabetes mellitusmicrobiotapermeability
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.